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Titolo:
Neuropharmacology of control of respiratory rhythm and pattern in mature mammals
Autore:
Haji, A; Takeda, R; Okazaki, M;
Indirizzi:
Toyama Med & Pharmaceut Univ, Fac Med, Dept Pharmacol, Toyama 9300194, Japan Toyama Med & Pharmaceut Univ Toyama Japan 9300194 Toyama 9300194, Japan
Titolo Testata:
PHARMACOLOGY & THERAPEUTICS
fascicolo: 3, volume: 86, anno: 2000,
pagine: 277 - 304
SICI:
0163-7258(200006)86:3<277:NOCORR>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
THYROTROPIN-RELEASING-HORMONE; NUCLEUS-TRACTUS-SOLITARIUS; GAMMA-AMINOBUTYRIC-ACID; NON-NMDA RECEPTORS; METABOTROPIC GLUTAMATE RECEPTORS; MEDULLARY INSPIRATORY NEURONS; ROSTRAL VENTROLATERAL MEDULLA; CAROTID-BODY CHEMORECEPTORS; PRE-BOTZINGER COMPLEX; KAPPA-OPIOID AGONIST;
Keywords:
respiration; neuronal control of breathing; neurotransmitters; neuromodulators; respiratory depressants; respiratory excitants;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
329
Recensione:
Indirizzi per estratti:
Indirizzo: Takeda, R Toyama Med & Pharmaceut Univ, Fac Med, Dept Pharmacol, 2630 Sugitani, Toyama 9300194, Japan Toyama Med & Pharmaceut Univ 2630 Sugitani Toyama Japan 9300194
Citazione:
A. Haji et al., "Neuropharmacology of control of respiratory rhythm and pattern in mature mammals", PHARM THERA, 86(3), 2000, pp. 277-304

Abstract

This review summarizes the current understanding of the neurotransmitters and neuromodulators that are involved, firstly, in respiratory rhythm and pattern generation, where glutamate plays an essential role in the excitatory mechanisms and glycine and gamma-aminobutyric acid mediate inhibitory postsynaptic effects, and secondly, in the transmission of input signals from the central and peripheral chemoreceptors and of motor outputs to respiratory motor neurons. Finally, neuronal mechanisms underlying respiratory modulations caused by respiratory depressants and excitants, such as general anesthetics, benzodiazepines, opioids, and cholinergic agents, are described. (C) 2000 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 22:40:27