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Titolo:
Effects of aging and gender on QT dispersion in an overtly healthy population
Autore:
Kassotis, J; Costeas, C; Bedi, AK; Tolat, A; Reiffel, J;
Indirizzi:
New York Hosp Cornell, New York Methodist Hosp, Clin Electrophysiol Serv, Div Cardiol, Brooklyn, NY 11215 USA New York Hosp Cornell Brooklyn NY USA 11215 rdiol, Brooklyn, NY 11215 USA Columbia Univ Coll Phys & Surg, Columbia Presbyterian Med Ctr, New York, NY 10032 USA Columbia Univ Coll Phys & Surg New York NY USA 10032 w York, NY 10032 USA
Titolo Testata:
PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY
fascicolo: 7, volume: 23, anno: 2000,
pagine: 1121 - 1126
SICI:
0147-8389(200007)23:7<1121:EOAAGO>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE MYOCARDIAL-INFARCTION; TORSADES-DE-POINTES; VENTRICULAR REPOLARIZATION; INTERVAL DISPERSION; FEMALE GENDER; RISK FACTOR; ARRHYTHMIAS; MARKER; DEATH; DRUGS;
Keywords:
QT dispersion; QT interval; torsades de pointes;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Kassotis, J New York Hosp Cornell, New York Methodist Hosp, Clin Electrophysiol Serv, Div Cardiol, 506 6th St, Brooklyn, NY 11215 USA New York Hosp Cornell 506 6th St Brooklyn NY USA 11215 215 USA
Citazione:
J. Kassotis et al., "Effects of aging and gender on QT dispersion in an overtly healthy population", PACE, 23(7), 2000, pp. 1121-1126

Abstract

The objective of this study was to measure the normal variation of QT dispersion (QT(d)) with respect to age and gen der. The QT interval is a measure of the duration of ventricular depolarization and repolarization, while the QT(d) is a measure of the variability of the ventricular recovery time. The QT(d) has been suggested as a means of identifying those patients at risk for sustained ventricular tachyarrythmias and sudden cardiac death (SCD). A total of 250 patients (120 women, 130 men; age range 20-86 years) were recruited for this study. The QT intervals were measured in each of the 12 standard leads of the electrocardiogram. Data are presented as mean (mu) +/- SD. The QT(d) did not vary significantly within the same gender. A significant difference (P < 0.001) was noted in QT(d) between men (age [mu] = 53.3 +/- 15.6 years, QT(d) = 0.044 +/- 0.019 s) and women (age [mu] = 52.1 +/-15.1 years, QT(d) = 0.034 +/- 0.015 s). Overall, men had a greater QT(d), while women had a longer QT. In conclusion, we found that men had a longer QT(d), which may explain the increased risk of SCD. However, women have a longer QT interval with a smaller QT(d). A longer QT(min), as opposed to a longer QT(max), is responsible for the shorter QT(d) in women. This longer QT(min) in women may predispose to an increased risk of drug induced torsades de pointes.

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Documento generato il 04/04/20 alle ore 08:02:59