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Titolo:
Inhibition of 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis by S-allylcysteine
Autore:
Balasenthil, S; Nagini, S;
Indirizzi:
Annamalai Univ, Fac Sci, Dept Biochem, Annamalainagar 608002, Tamil Nadu, India Annamalai Univ Annamalainagar Tamil Nadu India 608002 , Tamil Nadu, India
Titolo Testata:
ORAL ONCOLOGY
fascicolo: 4, volume: 36, anno: 2000,
pagine: 382 - 386
SICI:
1368-8375(200007)36:4<382:IO7HBP>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUTATHIONE-PEROXIDASE; GARLIC POWDER; DNA-ADDUCTS; TRANSFERASE; TISSUES; CANCER; CELLS;
Keywords:
oral cancer; DMBA; S-allylcysteine; chemoprevention; lipid peroxidation; antioxidants;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Nagini, S Annamalai Univ, Fac Sci, Dept Biochem, Annamalainagar 608002, Tamil Nadu, India Annamalai Univ Annamalainagar Tamil Nadu India 608002 du, India
Citazione:
S. Balasenthil e S. Nagini, "Inhibition of 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis by S-allylcysteine", ORAL ONCOL, 36(4), 2000, pp. 382-386

Abstract

Consumption of garlic has been reported to be associated with decreased risk of cancer. We used the 7,12-dimethylbenz[a]anthracene (DMBA)-induced hamster buccal pouch carcinoma model to assess the oral chemopreventive potential of S-allylcysteine (SAC), a water-soluble constituent of garlic. Hamsters were divided into four groups of six animals each. The right buccal pouches of the animals in group I were painted with a 0.5% solution of DMBA in liquid paraffin three times a week. The animals in group II were painted with DMBA as in group I and in addition received 200 mg/kg body weight SAC intragastrically three times a week on days alternate to DMBA application. Group III animals received SAC its in group II. Animals in group IV received neither DMBA nor SAC and served as control. The hamsters were killed after an experimental period of 14 weeks. Biochemical measurements were carried out on tumour and normal pouch tissues. Measurement of lipid peroxidation, reduced glutathione (GSH), glutathione peroxidase (GPx) and glutathione S-transferase (GST)was used to monitor the chemopreventive potential of SAG. All hamsters painted with DMBA alone for 14 weeks developed well-differentiated squamous cell carcinomas. Diminished lipid peroxidation in the oral tumour tissue was accompanied by a significant increase in the levels of GSH, GPx and GST. Administration of SAC significantly suppressed DMBA-induced oral carcinogenesis as revealed by the absence of neoplasms. The results of the present study suggest that garlic may exert its chemopreventive effects by modulating lipid peroxidation and enhancing the levels of GSI-I, GPx and GST. (C) 2000 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 19:35:06