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Titolo:
Temporal lobe epilepsy: a clinicopathological study with special referenceto temporal neocortical changes
Autore:
Nishio, S; Morioka, T; Hisada, K; Fukui, M;
Indirizzi:
Kyushu Univ, Fac Med, Inst Neurol, Dept Neurosurg, Fukuoka 8128582, Japan Kyushu Univ Fukuoka Japan 8128582 Dept Neurosurg, Fukuoka 8128582, Japan
Titolo Testata:
NEUROSURGICAL REVIEW
fascicolo: 2, volume: 23, anno: 2000,
pagine: 84 - 89
SICI:
0344-5607(200006)23:2<84:TLEACS>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONGENITAL MYOTONIC-DYSTROPHY; PRIMARY GENERALIZED EPILEPSY; NEUROPATHOLOGICAL FINDINGS; HIPPOCAMPAL SCLEROSIS; MICRODYSGENESIS; SEIZURES; CORTEX; CELLS; BRAIN; MRI;
Keywords:
cerebral microdysgenesis; hippocampal sclerosis; histopathology; temporal lobe epilepsy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Nishio, S 3-1-1 Maidashi,Higashi Ku, Fukuoka 8128582, Japan 3-1-1 Maidashi,Higashi Ku Fukuoka Japan 8128582 8128582, Japan
Citazione:
S. Nishio et al., "Temporal lobe epilepsy: a clinicopathological study with special referenceto temporal neocortical changes", NEUROSURG R, 23(2), 2000, pp. 84-89

Abstract

The number of patients undergoing surgical treatment for pharmacoresistanttemporal lobe epilepsy is rapidly increasing. While there have been many clinicopathological studies concerning the medial structures of the temporallobe in temporal lobe epilepsy, its lateral structures have received little attention. To examine the nature and frequency of lateral temporal lobe abnormalities that occur in temporal lobe epilepsy, 22 patients who underwent standard anterior temporal lobectomy with hippocampectomy for intractabletemporal lobe epilepsy were studied. The mean ages at the onset of seizureand at surgery were 15.9 years and 27.7 years, respectively. The electroclinically determined epileptogenic zones were the medial structures of the temporal lobe in 16 patients and the lateral in six. There was histologic evidence of hippocampal sclerosis in 12 of the 16 patients with medial onset seizures and in three of the six patients with lateral onset seizures. The lateral structures of the temporal lobe showed variable degrees of histological abnormalities in 21 patients. Among these abnormalities, heterotopic white matter neurons were observed in six of the 16 medial patients and in all the lateral patients. Glial changes were also common abnormalities, and often glial fibrillary acidic protein (GFAP)-positive astrocytes were present over the entire temporal lobe. In addition to hippocampal sclerosis, cerebral microdysgenesis and gliosis in the lateral structures of the temporallobe may have a significant role in epileptogenesis of temporal lobe epilepsy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 12:08:43