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Titolo:
Stereotactic radiosurgery of cerebral arteriovenous malformations with a multileaf collimator and a single isocenter
Autore:
Ross, DA; Sandler, HM; Balter, JM; Hayman, JA; Deveikis, J; Auer, DL;
Indirizzi:
Medford Neurol & Spine Clin, Medford, OR 97504 USA Medford Neurol & Spine Clin Medford OR USA 97504 n, Medford, OR 97504 USA Univ Michigan, Dept Surg, Neurosurg Sect, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 rosurg Sect, Ann Arbor, MI 48109 USA Univ Michigan, Dept Radiat Oncol, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 adiat Oncol, Ann Arbor, MI 48109 USA Univ Michigan, Dept Radiol, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 Dept Radiol, Ann Arbor, MI 48109 USA
Titolo Testata:
NEUROSURGERY
fascicolo: 1, volume: 47, anno: 2000,
pagine: 123 - 128
SICI:
0148-396X(200007)47:1<123:SROCAM>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOSE-RESPONSE ANALYSIS; GAMMA-KNIFE SURGERY; PATIENT OUTCOMES; BRAIN; OBLITERATION; AVMS; EMBOLIZATION; RADIOTHERAPY; MICROSURGERY; THERAPY;
Keywords:
arteriovenous malformation; multileaf collimator; radiosurgery;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Ross, DA Medford Neurol & Spine Clin, 2900 State St, Medford, OR 97504 USAMedford Neurol & Spine Clin 2900 State St Medford OR USA 97504 SA
Citazione:
D.A. Ross et al., "Stereotactic radiosurgery of cerebral arteriovenous malformations with a multileaf collimator and a single isocenter", NEUROSURGER, 47(1), 2000, pp. 123-128

Abstract

OBJECTIVE: To prospectively demonstrate the safety and efficacy of stereotactic radiosurgery for arteriovenous malformations (AVMs) of the brain witha linear accelerator fitted with a multileaf collimator. METHODS: A novel radiosurgery system was developed at the University of Michigan Medical Center with a standard multileaf collimator and a computer-controlled radiotherapy system. Data were accumulated prospectively on all patients undergoing treatment with this system since treatment began in 1995. RESULTS: Thirty-six patients with 37 AVMs have undergone treatment to date. At more than 3 years since treatment, 15 of 16 AVMs with a volume of lessthan 10 cc were proven to be obliterated by angiography or magnetic resonance imaging, and one was considered a treatment failure. At move than 24 months since therapy, all four AVMs with a volume of 10 to 25 cc were obliterated. Four patients with AVMs with a volume of more than 25 cc have undergone staged therapy, treating the entire volume to 10 Gy twice, but none has been followed long enough to demonstrate a final outcome. There were four transient and no permanent complications. CONCLUSION: Our early data indicate that stereotactic radiosurgery of cerebral AVMs with a linear accelerator and a multileaf collimator is safe and effective. Large AVMs may be especially suitable for this mode of therapy. Staged treatment of very large AVMs seems to be a promising addition to standard treatment, but longer follow-up is necessary to confirm that completeobliteration can be achieved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 06:38:41