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Titolo:
Low mini-mental status predicts mortality is asymptomatic carotid arterialstenosis
Autore:
Pettigrew, LC; Thomas, N; Howard, VJ; Veltkamp, R; Toole, JF;
Indirizzi:
Univ Kentucky, Chandler Med Ctr, Sanders Brown Ctr Aging, Coll Med,Dept Neurol, Lexington, KY 40536 USA Univ Kentucky Lexington KY USA 40536 Dept Neurol, Lexington, KY 40536 USA Univ Kentucky, Coll Med, Sanders Brown Ctr Aging, Stroke Program, Lexington, KY 40536 USA Univ Kentucky Lexington KY USA 40536 oke Program, Lexington, KY 40536 USA Univ N Carolina, Dept Biostat, Chapel Hill, NC USA Univ N Carolina ChapelHill NC USA na, Dept Biostat, Chapel Hill, NC USA Univ Alabama, Dept Epidemiol & Int Hlth, Birmingham, AL USA Univ Alabama Birmingham AL USA Epidemiol & Int Hlth, Birmingham, AL USA Wake Forest Univ, Bowman Gray Sch Med, Ctr Stroke Res, Winston Salem, NC USA Wake Forest Univ Winston Salem NC USA Stroke Res, Winston Salem, NC USA Wake Forest Univ, Bowman Gray Sch Med, Dept Neurol, Winston Salem, NC USA Wake Forest Univ Winston Salem NC USA Dept Neurol, Winston Salem, NC USA
Titolo Testata:
NEUROLOGY
fascicolo: 1, volume: 55, anno: 2000,
pagine: 30 - 34
SICI:
0028-3878(20000712)55:1<30:LMSPMI>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDARTERECTOMY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Pettigrew, LC Univ Kentucky, Chandler Med Ctr, Sanders Brown Ctr Aging, Coll Med,Dept Neurol, 101 Sanders Brown Bldg,800 S Limestone St, Lexington, KY 40536 USA Univ Kentucky 101 Sanders Brown Bldg,800 S Limestone St Lexington KY USA 40536
Citazione:
L.C. Pettigrew et al., "Low mini-mental status predicts mortality is asymptomatic carotid arterialstenosis", NEUROLOGY, 55(1), 2000, pp. 30-34

Abstract

Objective: To determine whether carotid endarterectomy is superior to bestmedical therapy in preserving cognition, and whether low Mini-Mental StateExamination (MMSE) scores predict TIA, stroke, myocardial infarction, or death. Methods: Subjects participating in the Asymptomatic Carotid Atherosclerosis Study were administered the MMSE at periodic intervals. Group means were calculated at randomization, 1 and 3 months later, and every 6 months thereafter. The group means were compared by treatment and over time. A proportional hazard regression model incorporating postrandomization MMSE score as a predictor variable was used to estimate risk of death, stroke, or other outcome events. Results: There was no intergroup difference in mean MMSE score during 5 years of observation. For individual patients, the relationship between a low postrandomization score on the MMSE and increased risk of death was significant (p less than or equal to 0.0001). Patients who experienced stroke after randomization also had a significant and persistent reduction in MMSE score (p less than or equal to 0.0001). Conclusions: Carotid endarterectomy had no impact on MMSE score in this study. Patients with low postrandomization MMSE scores had a greater likelihood of death. Strokereduced MMSE scores and may portend cognitive impairment. The authors recommend the routine inclusion of cognitive testing in future clinical trials designed to evaluate prophylaxis or acute therapy of stroke.

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Documento generato il 25/11/20 alle ore 06:24:26