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Titolo:
Targeting to rhoptry organelles of Toxoplasma gondii involves evolutionarily conserved mechanisms.
Autore:
Hoppe, HC; Ngo, HM; Yang, M; Joiner, KA;
Indirizzi:
Yale Univ, Sch Med, Dept Internal Med, Infect Dis Sect, New Haven, CT 06520 USA Yale Univ New Haven CT USA 06520 Infect Dis Sect, New Haven, CT 06520 USA
Titolo Testata:
NATURE CELL BIOLOGY
fascicolo: 7, volume: 2, anno: 2000,
pagine: 449 - 456
SICI:
1465-7392(200007)2:7<449:TTROOT>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANS-GOLGI NETWORK; DENSITY-LIPOPROTEIN RECEPTOR; INTRACELLULAR PARASITE; TRANSMEMBRANE DOMAINS; CYTOPLASMIC DOMAIN; SECRETORY PATHWAY; MEMBRANE-PROTEINS; SORTING SIGNALS; CELL-SURFACE; LDL RECEPTOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Joiner, KA Yale Univ, Sch Med, Dept Internal Med, Infect Dis Sect, 333 Cedar St, New Haven, CT 06520 USA Yale Univ 333 Cedar St New Haven CT USA 06520 ven, CT 06520 USA
Citazione:
H.C. Hoppe et al., "Targeting to rhoptry organelles of Toxoplasma gondii involves evolutionarily conserved mechanisms.", NAT CELL BI, 2(7), 2000, pp. 449-456

Abstract

Intracellular parasites of the phylum Apicomplexa contain specialized rhoptry secretory organelles that have a crucial function in host-cell invasionand establishment of the parasitophorous vacuole. Here we show that localization of the Toxoplasma gondii rhoptry protein ROP2 is dependent on a YEQLsequence in the cytoplasmic tail that binds to mu-chain subunits of T, gondii and mammalian adaptors, and conforms to the YXX phi mammalian sorting motif. Chimaeric reporters, containing the transmembrane domains and cytoplasmic tails of the low-density lipoprotein receptor and of Lamp-1, are sorted to the Golgi or the trans-Golgi network (TGN), and partially to apical microneme organelles of the parasite, respectively. Targeting of these reporters is mediated by YXX phi- and NPXY-type signals. This is the first demonstration of tyrosine-dependent sorting in protozoan parasites, indicating that T. gondii proteins may be targeted to, and involved in biogenesis of, morphologically unique organelles through the use of evolutionarily conservedsignals and machinery.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 10:38:00