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Titolo:
Time-dependent sensitization: the odyssey of a scientific heresy from the laboratory to the door of the clinic
Autore:
Antelman, SM; Levine, J; Gershon, S;
Indirizzi:
Univ Pittsburgh, Sch Med, Western Psychiat Inst & Clin, Dept Psychiat, Pittsburgh, PA 15213 USA Univ Pittsburgh Pittsburgh PA USA 15213 sychiat, Pittsburgh, PA 15213 USA
Titolo Testata:
MOLECULAR PSYCHIATRY
fascicolo: 4, volume: 5, anno: 2000,
pagine: 350 - 356
SICI:
1359-4184(200007)5:4<350:TSTOOA>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
PITUITARY-ADRENAL AXIS; LONG-LASTING CHANGES; INTRAVENOUS CLOMIPRAMINE; STRIATAL DOPAMINE; HORMONE CRH; MALE-RATS; STRESSOR; EXPOSURE; CORTICOSTERONE; SUBSENSITIVITY;
Keywords:
sensitization; stress; pulsed therapy; antidepressants; post-traumatic stress disorder; evolution; immunological memory;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
68
Recensione:
Indirizzi per estratti:
Indirizzo: Antelman, SM Univ Pittsburgh, Sch Med, Western Psychiat Inst & Clin, Dept Psychiat, 3811 OHara St, Pittsburgh, PA 15213 USA Univ Pittsburgh 3811 OHara St Pittsburgh PA USA 15213 213 USA
Citazione:
S.M. Antelman et al., "Time-dependent sensitization: the odyssey of a scientific heresy from the laboratory to the door of the clinic", MOL PSYCHI, 5(4), 2000, pp. 350-356

Abstract

This review provides both a biological and clinical perspective on Time-Dependent Sensitization (TDS), an ancient amplified memory response to threatmanifest in the ability of both drugs and nondrug stressors to induce neuronal and behavioral effects which strengthen entirely as a function of the passage of time following even a single or acute exposure. Evidence is presented to show that TDS may be involved in the development of a spectrum of diseases and how drug regimens based on the principles of TDS could providea novel and revolutionary means of treating psychiatric and other illnesses.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 15:42:11