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Titolo:
Theophylline in snoring and sleep-related breathing disorders: Sleep laboratory investigations on subjective and objective sleep and awakening quality
Autore:
Oberndorfer, S; Saletu, B; Gruber, G; Anderer, P; Saletu, M; Mandl, M; Saletu-Zyhlarz, G;
Indirizzi:
Rudolfinerhaus, Sleep Lab, Vienna, Austria Rudolfinerhaus Vienna Austria udolfinerhaus, Sleep Lab, Vienna, Austria Univ Vienna, Sch Med, Dept Psychiat, Vienna, Austria Univ Vienna Vienna Austria nna, Sch Med, Dept Psychiat, Vienna, Austria
Titolo Testata:
METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY
fascicolo: 4, volume: 22, anno: 2000,
pagine: 237 - 245
SICI:
0379-0355(200005)22:4<237:TISASB>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITIVE AIRWAY PRESSURE; EXCESSIVE DAYTIME SLEEPINESS; GENERALIZED ANXIETY DISORDER; NONORGANIC INSOMNIA; COGNITIVE FUNCTION; NONAPNEIC SNORERS; APNEA SYNDROME; RISK FACTOR; FRAGMENTATION; HYPERTENSION;
Keywords:
sleep apnea; obstructive snoring; primary snoring; theophylline; polysomnography; subjective and objective sleep and awakening quality;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: Saletu, B Univ Vienna, Sect Sleep Res & Pharmacopsychiat, Wahringer Gurtel18-20, A-1090 Vienna, Austria Univ Vienna Wahringer Gurtel 18-20 Vienna Austria A-1090 ustria
Citazione:
S. Oberndorfer et al., "Theophylline in snoring and sleep-related breathing disorders: Sleep laboratory investigations on subjective and objective sleep and awakening quality", METH FIND E, 22(4), 2000, pp. 237-245

Abstract

The aim of the present investigation was to comparatively examine the effect of theophylline on various sleep-related breathing disorders of different severity. In a single-blind, placebo-controlled crossover study, 30 patients were polysomnographically diagnosed as suffering from primary snoring (n = 7), obstructive snoring (n = 12) or moderate sleep apnea (n = 11). Subsequent polysomnographic investigations included one baseline, one placebo and one theophylline (Respicur(R) retard 400 mg, Byk Gulden, Konstanz, Germany) night. Subjective sleep and awakening quality was evaluated by means ofa test battery completed in the morning. Concerning respiratory variables,theophylline was most effective in patients with moderate sleep apnea. Obstructive snorers only showed a tendency towards improvement and primary snorers remained unchanged. Sleep architecture generally remained unchanged inall three patient groups. Objective awakening quality was partly improved in primary snorers, obstructive snorers, as well as in moderate sleep apneapatients as compared with baseline, bur not as compared with placebo. Regarding subjective sleep and awakening quality, only primary snorers and an improvement, as compared with baseline while sleep apnea patients remained unchanged. Based on intergroup comparison, we conclude that patients with moderate sleep apnea showed the most pronounced improvement in regard to respiratory events. Concerning sleep initiation and maintenance, sleep architecture and subjective sleep and awakening anality, no significant intergroup differences were found. Regarding objective awakening quality, attention showed a significantly greater improvement in primary than in obstructive snorers and sleep apnea patients, while motor performance was most improved inobstructive snorers. (C) 2000 Prous Science. All rights reserved.

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Documento generato il 02/07/20 alle ore 19:03:46