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Titolo:
Diclofenac sodium (Voltaren) reduced exercise-induced injury in human skeletal muscle
Autore:
OGrady, M; Hackney, AC; Schneider, K; Bossen, E; Steinberg, K; Douglas, JM; Murray, WJ; Watkins, WD;
Indirizzi:
Emory Univ, Dept Rehabil Med, Sch Med, Wesley Wood Geriatr Hosp, Atlanta, GA 30322 USA Emory Univ Atlanta GA USA 30322 Wood Geriatr Hosp, Atlanta, GA 30322 USA Univ N Carolina, Appl Physiol Lab, Endocrine Sect, Chapel Hill, NC USA Univ N Carolina Chapel Hill NC USA , Endocrine Sect, Chapel Hill, NC USA Duke Univ, Med Ctr, Dept Pathol, Durham, NC 27710 USA Duke Univ Durham NCUSA 27710 Med Ctr, Dept Pathol, Durham, NC 27710 USA Duke Univ, Med Ctr, Dept Surg, Durham, NC 27710 USA Duke Univ Durham NC USA 27710 v, Med Ctr, Dept Surg, Durham, NC 27710 USA Duke Univ, Med Ctr, Dept Anesthesiol, Durham, NC 27710 USA Duke Univ Durham NC USA 27710 Ctr, Dept Anesthesiol, Durham, NC 27710 USA Family Med, San Diego, CA USA Family Med San Diego CA USAFamily Med, San Diego, CA USA
Titolo Testata:
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
fascicolo: 7, volume: 32, anno: 2000,
pagine: 1191 - 1196
SICI:
0195-9131(200007)32:7<1191:DS(REI>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
LENGTHENING CONTRACTIONS; SORENESS; DAMAGE; MECHANISMS; FIBERS; MICE; DRUG;
Keywords:
nonsteroidal anti-inflammatory drugs; muscle damage;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: O'Grady, M Emory Univ, Dept Rehabil Med, Sch Med, Wesley Wood Geriatr Hosp, 1841 Clifton Rd NE, Atlanta, GA 30322 USA Emory Univ 1841 Clifton Rd NE Atlanta GA USA 30322 GA 30322 USA
Citazione:
M. O'Grady et al., "Diclofenac sodium (Voltaren) reduced exercise-induced injury in human skeletal muscle", MED SCI SPT, 32(7), 2000, pp. 1191-1196

Abstract

Purpose: To examine the effects of prolonged systemic administration of diclofenac sodium (Voltaren), a nonsteroidal anti-inflammatory drug, on objective indices of exercise-induced muscle damage in humans. Methods: Fifty-four volunteers (mean age, 26.4 yr; range, 18-35) participated in this randomized double-blind, placebo-controlled trial. To achieve steady-state tissuelevels, either placebo or diclofenac was orally administered two limes a day for 27 consecutive days. A strenuous 20-min stepping exercise program, about which the subjects were unfamiliar, was conducted on day 15. Creatine kinase (CK) activities were measured immediately before the exercise session and on days 16, 18, and 27. Vastus lateralis muscle samples were obtainedimmediately before exercise and on day 27 for subsequent histological characterization of muscle inflammation. Results: The preexercise muscle samples revealed no difference in muscle damage between the two groups. However, the postexercise muscle samples showed that the diclofenac-treated group demonstrated less muscle tissue damage than placebo-treated subjects (P = 0.002). The administration of diclofenac also resulted in a significant lowering of post-/pre-exercise CK ratios on days 18 (P = 0.03) and 27 (P = 0.02) compared with the placebo group, an indirect finding that supports the possibility of diclofenac reducing exercise-induced muscle damage. Conclusion: These findings demonstrate preadministration of diclofenac (in accordance with tissue half-life phamacokinetics) significantly reduces quantitative indices of exercise-induced skeletal muscle damage in human muscle.

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Documento generato il 09/04/20 alle ore 12:52:52