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Titolo:
ARSENIC METHYLATION CAPACITY, BODY RETENTION, AND NULL GENOTYPES OF GLUTATHIONE-S-TRANSFERASE M1 AND T1 AMONG CURRENT ARSENIC-EXPOSED RESIDENTS IN TAIWAN
Autore:
CHIOU HY; HSUEH YM; HSIEH LL; HSU LI; HSU YH; HSIEH FI; WEI ML; CHEN HC; YANG HT; LEU LC; CHU TH; CHENWU C; YANG MH; CHEN CJ;
Indirizzi:
NATL TAIWAN UNIV,COLL PUBL HLTH,GRAD INST EPIDEMIOL,1 JEN AI RD SECT 1 TAIPEI 100 TAIWAN NATL TAIWAN UNIV,COLL PUBL HLTH,GRAD INST EPIDEMIOL TAIPEI 100 TAIWAN TAIPEI MED COLL,SCH PUBL HLTH TAIPEI 110 TAIWAN TAIPEI MED COLL,DEPT PUBL HLTH TAIPEI 110 TAIWAN CHANG GUNG MED COLL,DEPT PUBL HLTH TAYUAN 333 TAIWAN NATL TSING HUA UNIV,DEPT NUCL SCI HSINCHU 300 TAIWAN
Titolo Testata:
Mutation research-reviews in mutation research
fascicolo: 3, volume: 386, anno: 1997,
pagine: 197 - 207
Fonte:
ISI
Lingua:
ENG
Soggetto:
DISEASE ENDEMIC AREA; ARTESIAN WELL WATER; MALIGNANT NEOPLASMS; BLACKFOOT DISEASE; URINARY CONCENTRATIONS; CANCER SUSCEPTIBILITY; GENETIC-POLYMORPHISM; DRINKING-WATER; BLADDER-CANCER; COLON-CANCER;
Keywords:
ARSENIC; METHYLATION; BODY RETENTION; GLUTATHIONE S-TRANSFERASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
49
Recensione:
Indirizzi per estratti:
Citazione:
H.Y. Chiou et al., "ARSENIC METHYLATION CAPACITY, BODY RETENTION, AND NULL GENOTYPES OF GLUTATHIONE-S-TRANSFERASE M1 AND T1 AMONG CURRENT ARSENIC-EXPOSED RESIDENTS IN TAIWAN", Mutation research-reviews in mutation research, 386(3), 1997, pp. 197-207

Abstract

In order to elucidate the relationships among arsenic methylation capacity, body retention, and genetic polymorphisms of glutathione S-transferase (GST) MI and T1, a total of 115 study subjects were recruited from Lanyang Basin located on the northeast coast of Taiwan. Specimensof drinking water, blood, urine, hair and toenail were collected fromeach study subject. Urinary inorganic and methylated arsenic were speciated by high performance liquid chromatography combined with hydride-generation atomic absorption spectrometry. Arsenic concentration in hair and toenail were quantitated by atomic absorption spectrophotometry. The polymerase chain reaction was used to determine genetic polymorphisms of GST M1 and T1, Arsenic concentrations in urine, hair, and toenail of study subjects were positively correlated with arsenic levelsin their drinking water, Percentages of various arsenic species in urine (mean +/- standard error (SE)) were 11.8 +/- 1.0, 26.9 +/- 1.2 and61.3 +/- 1.4, respectively, for inorganic arsenic, monomethylarsonic acid (MMA) and dimethylarsinic acid (DMA). Men and women had similar arsenic methylation capability. No associations were observed between arsenic methylation capability and arsenic content in either drinking water or urine. Ratios of arsenic contents in hair and toenail to urinary arsenic content (mean +/- standard error) were 6.2 +/- 0.7 and 16.5+/- 1.7, respectively. Genetic polymorphisms of GST M1 and T1 were significantly associated with arsenic methylation. Subjects having the nun genotype of GST M1 had an increased percentage of inorganic arsenicin urine, while those with null genotype of GST T1 had an elevated percentage of DMA in urine, Arsenic contents in hair and toenail were significantly correlated with the increase in arsenic concentrations of drinking water and urine, while no significant associations were observed between arsenic contents in hair and toenail and polymorphisms of GST M1 and T1. The relationship between arsenic methylation capabilityand body retention was modified by genetic polymorphisms of GST M1 and T1. Arsenic contents in hair and toenail were negatively associated with MMA percentage and positively associated with DMA percentage among subjects having null genotypes of GST M1 and T1, but not among thosewith non-null genotypes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 01:20:24