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Titolo:
Alzheimer beta-amyloid precursor proteins display specific patterns of expression during embryogenesis
Autore:
Sarasa, M; Sorribas, V; Terrado, J; Climent, S; Palacios, JM; Mengod, G;
Indirizzi:
Univ Zaragoza, Dept Anat Embryol & Genet, Neurobiol Lab, E-50013 Zaragoza,Spain Univ Zaragoza Zaragoza Spain E-50013 urobiol Lab, E-50013 Zaragoza,Spain Univ Zaragoza, Dept Toxicol, Neurobiol Lab, E-50013 Zaragoza, Spain Univ Zaragoza Zaragoza Spain E-50013 robiol Lab, E-50013 Zaragoza, Spain Labs Almirall Prodesfarma, E-08024 Barcelona, Spain Labs Almirall Prodesfarma Barcelona Spain E-08024 08024 Barcelona, Spain CSIC, IIBB, Dept Neurochem, E-08036 Barcelona, Spain CSIC Barcelona Spain E-08036 B, Dept Neurochem, E-08036 Barcelona, Spain
Titolo Testata:
MECHANISMS OF DEVELOPMENT
fascicolo: 1-2, volume: 94, anno: 2000,
pagine: 233 - 236
SICI:
0925-4773(200006)94:1-2<233:ABPPDS>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENE-RELATED PEPTIDE; RAT-BRAIN; ALPHA-TYPE;
Keywords:
beta-amyloid precursor protein (beta APP); Alzheimer's disease; RNA splicing; gene expression; early development; embryogenesis; morphogenesis; expression pattern; nervous system; in situ hybridization histochemistry; rat embryo;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
6
Recensione:
Indirizzi per estratti:
Indirizzo: Sarasa, M Univ Zaragoza, Dept Anat Embryol & Genet, Neurobiol Lab, Miguel Servet 177, E-50013 Zaragoza, Spain Univ Zaragoza Miguel Servet 177 Zaragoza Spain E-50013 a, Spain
Citazione:
M. Sarasa et al., "Alzheimer beta-amyloid precursor proteins display specific patterns of expression during embryogenesis", MECH DEVEL, 94(1-2), 2000, pp. 233-236

Abstract

The beta-amyloid precursor proteins (beta APPs) are a family of glycosylated transmembrane proteins that include in their sequences the beta-amyloid peptide, a major component of the characteristic amyloid deposits or senileplaques found in the brains of Alzheimer's disease patients and aged Down's syndrome subjects. Various beta APP isoforms, mainly beta APP-695, beta APP-714, beta APP-751 and beta APP-770, the number corresponding to the number of amino acids they encode, resulting from the alternative splicing of asingle primary transcript have been described. Using oligonucleotides recognizing each of the four major Alzheimer's beta APP mRNAs, we have found that each beta APP mRNA displays a specific temporal and spatial pattern of expression. The prototype isoform beta APP-695 occurs early in cells actively implicated in morphogenetic events, as those mesodermal cells invaginating at the level of the primitive streak, and it is later restricted to the neurectodermal (neural tube, neural crest and neurogenic placode) derivatives. By contrast, the longest isoform beta APP-770 appears later and restricted to mesodermal and endodermal derivatives. The isoforms beta APP-714 and beta APP-751;ve still expressed later than the other two isoforms and distributed ubiquitously, though beta APP-714 transcripts predominate typically within the neural tube. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 01:57:39