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Titolo:
Abnormal late responses upon transcranial magnetic stimulation in patientswith Stiff Man Syndrome
Autore:
Schulte-Mattler, WJ; Deschauer, M; Kornhuber, M; Zierz, S;
Indirizzi:
Univ Halle Wittenberg, Neurol Klin & Poliklin, D-06097 Halle, Germany UnivHalle Wittenberg Halle Germany D-06097 klin, D-06097 Halle, Germany
Titolo Testata:
KLINISCHE NEUROPHYSIOLOGIE
fascicolo: 2, volume: 31, anno: 2000,
pagine: 59 - 64
SICI:
1434-0275(200006)31:2<59:ALRUTM>2.0.ZU;2-F
Fonte:
ISI
Lingua:
GER
Soggetto:
PROGRESSIVE ENCEPHALOMYELITIS; STARTLE REFLEX; RIGIDITY;
Keywords:
Stiff Man Syndrome; magnetic stimulation; late responses; silent period;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Schulte-Mattler, WJ Univ Halle Wittenberg, Neurol Klin & Poliklin, Ernst Grube Str 40, D-06097Halle, Germany Univ Halle Wittenberg Ernst Grube Str 40Halle Germany D-06097
Citazione:
W.J. Schulte-Mattler et al., "Abnormal late responses upon transcranial magnetic stimulation in patientswith Stiff Man Syndrome", KLIN NEUROP, 31(2), 2000, pp. 59-64

Abstract

Introduction: Stiff Man Syndrome (SMS) is a rare disorder characterised byfluctuating stiffness of axial and proximal limb muscles. The diagnosis ismade on clinical signs and symptoms. Elevated titers of antibodies againstglutamic acid decarboxylase support the diagnosis. Abnormal late responses(LRs) upon transcranial stimulation (TMS) were found in a patient with SMS. We report on the follow-up of this patient and on TMS findings in anotherpatient with SMS. Methods: Cortex and lumbar plexus were stimulated with amagnetic stimulator. Compound muscle action potentials from anterior tibial muscles were recorded with surface electrodes in the patients and in 22 healthy controls. Results: Upon TMS, in both patients primary responses werenormal, but there were LRs with a latency of 69 ms and 67 ms, respectively. The LRs were independent of an attack of stiffness and did not habituate. In the first patient, treatment with diazepam was clinically effective. The LRs were abolished after treatment and did not recur during the following2 years. In the second patient, treatment with immunoglobulins in additionto benzodiazepines was clinically effective. After this treatment LRs disappeared only in the right leg. Discussion: The LRs were abnormal because they occurred within the physiological silent period. The correspondence between the presence of the LRs and the patients, symptoms indicates that the LRs are part of SMS. In contrast to other electrophysiological findings in SMS, such as spasmodic reflex myoclonus, the LRs showed no habituation. TMS may be a simple test for SMS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 03:54:28