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Titolo:
Effects of aging and dietary restriction on mRNA levels of receptors for growth hormone-releasing hormone and somatostatin in the rat pituitary
Autore:
Shimokawa, I; Yanagihara, K; Higami, Y; Okimoto, T; Tomita, M; Ikeda, T; Lee, S;
Indirizzi:
Nagasaki Univ, Sch Med, Dept Pathol, Nagasaki 8528523, Japan Nagasaki Univ Nagasaki Japan 8528523 ept Pathol, Nagasaki 8528523, Japan Univ Texas, Hlth Sci Ctr, Dept Physiol, San Antonio, TX 78284 USA Univ Texas San Antonio TX USA 78284 pt Physiol, San Antonio, TX 78284 USA
Titolo Testata:
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
fascicolo: 6, volume: 55, anno: 2000,
pagine: B274 - B279
SICI:
1079-5006(200006)55:6<B274:EOAADR>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
OLD MALE-RATS; MESSENGER-RNA; MOLECULAR-CLONING; BINDING-SITES; AGED RATS; RT-PCR; EXPRESSION; SUBTYPES; INVITRO; SOMATOTROPHS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Shimokawa, I Nagasaki Univ, Sch Med, Dept Pathol, 1-12-4 Sakamoto, Nagasaki 8528523, Japan Nagasaki Univ 1-12-4 Sakamoto Nagasaki Japan 8528523 , Japan
Citazione:
I. Shimokawa et al., "Effects of aging and dietary restriction on mRNA levels of receptors for growth hormone-releasing hormone and somatostatin in the rat pituitary", J GERONT A, 55(6), 2000, pp. B274-B279

Abstract

Aging impairs and dietary restriction may modulate pituitary response to growth hormone (CH)-releasing hormone (GHRH) and somatostatin (SRIH) for GH secretion. Using the semiquantitative reverse-transcription polymerase chain reaction method, we analyzed the mRNA levels of the GHRH receptor (grfr) and SRIH receptor subtype 2 (sstr2) and subtype 5 (sstr5) in anterior pituitaries of male rats fed ad libitum or 30% dietary restricted. Aging reducedthe mRNA levels of these receptors in a slightly different manner. The levels of grfr progressively decreased between 6 and 24 months, whereas those of sstr2 and sstr5 declined after 16 months. Dietary restriction did not diminish the aging-dependent changes, although it slightly augmented the levels of grfr, but not sstr2 and sstr5. The present results suggest that the aging-dependent impairment in pituitary response for GH secretion could result mostly from a decline in grfr rather than relative increase of sstrs, Although DR could slightly enhance the pituitary sensitivity to GARH, the antiaging action may be minor at the level of gene expression.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 08:10:28