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Titolo:
Mature dendritic cells infected with herpes simplex virus type 1 exhibit inhibited T-cell stimulatory capacity
Autore:
Kruse, M; Rosorius, O; Kratzer, F; Stelz, G; Kuhnt, C; Schuler, G; Hauber, J; Steinkasserer, A;
Indirizzi:
Univ Erlangen Nurnberg, Dept Dermatol, D-91052 Erlangen, Germany Univ Erlangen Nurnberg Erlangen Germany D-91052 -91052 Erlangen, Germany Univ Erlangen Nurnberg, Inst Clin & Mol Virol, Erlangen, Germany Univ Erlangen Nurnberg Erlangen Germany & Mol Virol, Erlangen, Germany
Titolo Testata:
JOURNAL OF VIROLOGY
fascicolo: 15, volume: 74, anno: 2000,
pagine: 7127 - 7136
SICI:
0022-538X(200008)74:15<7127:MDCIWH>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN BLOOD; INFLUENZA-VIRUS; MEASLES-VIRUS; ANTIGEN PRESENTATION; LYMPHOCYTES-T; MATURATION; GENERATION; RESPONSES; IMMUNITY; SUPERFAMILY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Kruse, M Univ Erlangen Nurnberg, Dept Dermatol, Hartmannstr 14, D-91052 Erlangen, Germany Univ Erlangen Nurnberg Hartmannstr 14 Erlangen Germany D-91052 y
Citazione:
M. Kruse et al., "Mature dendritic cells infected with herpes simplex virus type 1 exhibit inhibited T-cell stimulatory capacity", J VIROLOGY, 74(15), 2000, pp. 7127-7136

Abstract

Mature dendritic cells (DC) are the most potent antigen-presenting cells within the entire immune system. Interference with the function of these cells therefore constitutes a very powerful mechanism for viruses to escape immune responses. Several members of the Herpesviridae family have provided examples of such escape strategies, including interference with antigen presentation and production of homologous cytokines, In this study we investigated the infection of mature DC with herpes simplex virus type 1 (HSV-1) andthe way in which infection alters the phenotype and function of mature DC. Interestingly, the T-cell-stimulatory capacity of these DC was strongly impaired, Furthermore, we demonstrated that HSV-1 leads to the specific degradation of CD83, a cell surface molecule which is specifically upregulated during DC maturation. These data indicate that HSV-1 has developed yet another novel mechanism to escape immune responses.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 05:25:57