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Titolo:
Thyroid hyperactivity induced by methimazole, spironolactone and phenobarbital in marmosets (Callithrix jacchus): Histopathology, plasma thyroid hormone levels and hepatic T-4 metabolism
Autore:
Kurata, Y; Wako, Y; Tanaka, K; Inoue, Y; Makinodan, F;
Indirizzi:
Mitsubishi Chem Safety Inst Ltd, Hasaki, Ibaraki 3140255, Japan MitsubishiChem Safety Inst Ltd Hasaki Ibaraki Japan 3140255 40255, Japan Mitsubishi Tokyo Pharmaceut Inc, Clin Dev Dept, Chuo Ku, Tokyo 1038405, Japan Mitsubishi Tokyo Pharmaceut Inc Tokyo Japan 1038405 Tokyo 1038405, Japan Mitsubishi Tokyo Pharmaceut Inc, Yokohama Res Ctr, Aoba Ku, Kanagawa 2270033, Japan Mitsubishi Tokyo Pharmaceut Inc Kanagawa Japan 2270033 wa 2270033, Japan
Titolo Testata:
JOURNAL OF VETERINARY MEDICAL SCIENCE
fascicolo: 6, volume: 62, anno: 2000,
pagine: 607 - 614
SICI:
0916-7250(200006)62:6<607:THIBMS>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
THYROXINE; RAT; BINDING; SERUM; PROTEINS; DRUGS;
Keywords:
marmoset; methimazole; phenobarbital; spironolactone; thyroid hyperactivity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Kurata, Y Mitsubishi Chem Safety Inst Ltd, 14 Sunayama, Hasaki, Ibaraki 3140255, Japan Mitsubishi Chem Safety Inst Ltd 14 Sunayama Hasaki Ibaraki Japan 3140255
Citazione:
Y. Kurata et al., "Thyroid hyperactivity induced by methimazole, spironolactone and phenobarbital in marmosets (Callithrix jacchus): Histopathology, plasma thyroid hormone levels and hepatic T-4 metabolism", J VET MED S, 62(6), 2000, pp. 607-614

Abstract

To determine drug-induced hyperfunction of marmoset thyroids due to inhibition of synthesis or enhancement of metabolic elimination of thyroid hormones, males were orally administered 10 and 30 mg/kg/day methimazole (MMI), 30 and 100 mg/kg/day spironolactone (SPL), or 50 mg/kg/day phenobarbital (PB) for 4 weeks. MMI caused marked hypertrophy of follicular epithelial cellsin accordance with a significant decrease in the plasma thyroxin (T-4) level. Hypertrophied epithelial cells were filled with dilated rough endoplasmic reticulum and reabsorbed intracellular colloids, and the luminal surfacewas covered with abundant microvilli. The colloid included vacuoles positive to anti T-4 immune-staining. SPL and PB also caused similar histomorphological changes, although they were less severe than those due to MMI and were not clearly associated with decrease in the plasma T-4 levels. Hepatic T-4 UDPGT activities tended to increase due to SPL and PB treatment, however, which were not so significant as increases in microsomal cytochrome P-450contents. Some animals treated with SPL and PB showed marked increases in thyroid weights due to inactive dilated follicles. In conclusion, hyperactivity of thyroid follicles was induced in marmosets not only due to inhibition of T-4 synthesis produced by MMI but also because of enhancement of hepatic T-4 elimination produced by SPL and PB. However, hypertrophic effects of SPL and PB were less severe than MMI, because plasma T-4 levels were maintained at almost pretreatment or control levels after SPL or PB treatment.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 19:58:15