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Titolo:
Administration of granulocyte colony-stimulating factor enhances endothelialization and microvessel formation in small-caliber synthetic vascular grafts
Autore:
Bhattacharya, V; Shi, Q; Ishida, A; Sauvage, LR; Hammond, WP; Wu, MHD;
Indirizzi:
Hope Heart Inst, Dept Expt Surg, Seattle, WA 98122 USA Hope Heart Inst Seattle WA USA 98122 ept Expt Surg, Seattle, WA 98122 USA Univ Washington, Sch Med, Providence Seattle Med Ctr, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 attle Med Ctr, Seattle, WA 98195 USA Univ Washington, Sch Med, Dept Surg, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 ed, Dept Surg, Seattle, WA 98195 USA Univ Washington, Sch Med, Dept Med, Seattle, WA 98195 USA Univ WashingtonSeattle WA USA 98195 Med, Dept Med, Seattle, WA 98195 USA
Titolo Testata:
JOURNAL OF VASCULAR SURGERY
fascicolo: 1, volume: 32, anno: 2000,
pagine: 116 - 122
SICI:
0741-5214(200007)32:1<116:AOGCFE>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
MUSCLE CELL-PROLIFERATION; IMPERVIOUS DACRON GRAFTS; SMOOTH-MUSCLE; BLOOD; ARTERIAL; TRANSPLANTATION; DOG; ANGIOGENESIS; ENDOTHELIUM; PROSTHESES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Wu, MHD Hope Heart Inst, Dept Expt Surg, 528 18th Ave, Seattle, WA 98122 USA Hope Heart Inst 528 18th Ave Seattle WA USA 98122 le, WA 98122 USA
Citazione:
V. Bhattacharya et al., "Administration of granulocyte colony-stimulating factor enhances endothelialization and microvessel formation in small-caliber synthetic vascular grafts", J VASC SURG, 32(1), 2000, pp. 116-122

Abstract

Objective: The purpose of this study was to determine whether systemic administration of granulocyte colony-stimulating factor (G-CSF) would promote endothelialization for small-caliber Dacron vascular grafts. Methods: We implanted 4-mm preclotted Dacron grafts in both carotids of 12dogs. For a fair comparison, all dogs had a comparable platelet aggregation profile with platelet aggregation scores less than 30. Five dogs served as controls, and the others were given 7-day subcutaneous injections of G-CSF (10 mu g/kg per day), starting on the seventh postoperative day. The effect of G-CSF was evaluated by white blood cell count, which showed a 3.7-fold (+/- 2.7-fold) increase at the end of treatment. Grafts were harvested at4 weeks. All G-CSF grafts were patent, and one control occluded. Endothelial-like cell coverage averaged 80.8% on G-CSF grafts, but only 35.6% for control grafts (P < .0004). With the exclusion of the anastomotic pannus healing factor, the difference in endothelial-like cell coverage was even greater (68.5% vs 9.8%; P < .0001). Immunocytochemical staining and electron microscopy studies demonstrated endothelial cells. Light microscopy also showed that there were more microvessels on and in the G-CSF grafts than in the control grafts. This study suggests that G-CSP can enhance early endothelialization of small-caliber vascular grafts. Further studies to determine theproper dosage and timing are needed before clinical application can be recommended.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 12:27:34