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Titolo:
Effect of voluntary weight loss on bone mineral density in older overweight women
Autore:
Chao, D; Espeland, MA; Farmer, D; Register, TC; Lenchik, L; Applegate, WB; Ettinger, WH;
Indirizzi:
Wake Forest Univ, Bowman Gray Sch Med, Winston Salem, NC USA Wake Forest Univ Winston Salem NC USA ray Sch Med, Winston Salem, NC USA Univ Calif Davis, Davis, CA 95616 USA Univ Calif Davis Davis CA USA 95616Univ Calif Davis, Davis, CA 95616 USA London Sch Hyg & Trop Med, Med Stat Unit, London WC1, England London Sch Hyg & Trop Med London England WC1 t Unit, London WC1, England
Titolo Testata:
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
fascicolo: 7, volume: 48, anno: 2000,
pagine: 753 - 759
SICI:
0002-8614(200007)48:7<753:EOVWLO>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
RANDOMIZED CONTROLLED TRIAL; POSTMENOPAUSAL WOMEN; BODY-COMPOSITION; ELDERLY TONE; MASS; HYPERTENSION; TURNOVER; THERAPY; DIET; METABOLISM;
Keywords:
weight loss; bone loss; postmenopausal women;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Chao, D Univ Calif Davis, 4150 V St,Suite 2500,Patient Support Serv Bldg, Sacramento, CA 95817 USA Univ Calif Davis 4150 V St,Suite 2500,Patient Support Serv Bldg Sacramento CA USA 95817
Citazione:
D. Chao et al., "Effect of voluntary weight loss on bone mineral density in older overweight women", J AM GER SO, 48(7), 2000, pp. 753-759

Abstract

OBJECTIVES: To examine the effect of diet and exercise-induced weight losson bone mineral density in overweight postmenopausal women. DESIGN: A I-year prospective, randomized clinical trial. SETTING: Two university medical school research centers. PARTICIPANTS: Sixty-seven overweight postmenopausal women, a subset of thewomen who participated in the Trial of Nonpharmacological Interventions inthe Elderly (TONE) to control hypertension. The participants were assignedrandomly to one of four groups: usual care, weight loss only, sodium restriction only, or combined weight loss/sodium restriction. INTERVENTION: All TONE participants in the treatment groups attended regular dietary intervention sessions to lose weight, reduce sodium intake, or both that they might refrain from using antihypertensive medications for a period of 15 to 36 months (median = 29 months). MEASUREMENTS: Bone mineral density (BMD) assessed by dual energy X-ray absorptiometry (DXA), serum and urine markers of bone metabolism, and other demographic and clinical data were collected at baseline, 6 months, and 12 months. RESULTS: Women assigned to the weight loss interventions lost 9.2 +/- 1.2 lbs (mean +/- SE) at 6 months and 7.7 +/- 2.0 lbs at 12 months compared with 1.8 +- 1.0 Ibs at 6 months and 1.9 +/- 1,6 Ibs at 12 months for those assigned to no weight loss intervention (P <.0001). Weight loss was correlatedwith a decrease in total body BMD (P =.004) and an increase in osteocalcin(P =.004) after controlling for baseline bone measures, intervention assignment, and other baseline covariates. Regression analyses indicated that total body BMD decreased by 6.25 +/- 2.06 g/cm(2) x 10(-4) for each pound of -weight loss. CONCLUSIONS: Voluntary weight loss in overweight postmenopausal women is associated with modest decrease in total body BMD. Clinicians recommending weight loss for older postmenopausal women may need to include recommendations for reducing the risk of bone loss.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 19:56:14