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Titolo:
Low density lipoprotein cholesterol and coronary microvascular dysfunctionin hypercholesterolemia
Autore:
Kaufmann, PA; Gnecchi-Ruscone, T; Schafers, KP; Luscher, TF; Camici, PG;
Indirizzi:
Hammersmith Hosp, MRC, Cyclotron Unit, Clin Sci Ctr,Imperial Coll Sch Med,London W12 0NN, England Hammersmith Hosp London England W12 0NN Sch Med,London W12 0NN, England Univ Zurich Hosp, CH-8091 Zurich, Switzerland Univ Zurich Hosp Zurich Switzerland CH-8091 CH-8091 Zurich, Switzerland
Titolo Testata:
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
fascicolo: 1, volume: 36, anno: 2000,
pagine: 103 - 109
SICI:
0735-1097(200007)36:1<103:LDLCAC>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIUM-DEPENDENT RELAXATION; MYOCARDIAL BLOOD-FLOW; POSITRON EMISSION TOMOGRAPHY; FAMILIAL COMBINED HYPERLIPIDEMIA; SUPEROXIDE ANION PRODUCTION; ARTERY DISEASE; LOWERING THERAPY; NITRIC-OXIDE; FED RABBITS; CALCIUM-ANTAGONISTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
74
Recensione:
Indirizzi per estratti:
Indirizzo: Kaufmann, PA Hammersmith Hosp, MRC, Cyclotron Unit, Clin Sci Ctr,Imperial Coll Sch Med,London W12 0NN, England Hammersmith Hosp London England W12 0NN on W12 0NN, England
Citazione:
P.A. Kaufmann et al., "Low density lipoprotein cholesterol and coronary microvascular dysfunctionin hypercholesterolemia", J AM COL C, 36(1), 2000, pp. 103-109

Abstract

OBJECTIVES The present study evaluates the impact of total cholesterol (TC) and its subfractions on coronary flow reserve (CFR), an index of the integrated function of the coronary circulation, in asymptomatic subjects. BACKGROUND Endothelial dysfunction of the coronary microcirculation has been reported in asymptomatic subjects with hypercholesterolemia. METHODS Using oxygen-15-labeled water and positron emission tomography, myocardial blood flow (MBF, in ml/min per g) was measured at rest and during intravenous adenosine (140 mu g/kg body weight per min) in 80 asymptomatic nonsmoking men: group 1 (n = 61; age 45 +/- 7 years) had normal TC (less than or equal to 6.5 mmol/liter or less than or equal to 250 mg/dl) and group2 (n = 19; age 48 +/- 10 years) had elevated TC. RESULTS Total cholesterol were 5.1 +/- 0.8 and 7.2 +/- 0.7 mmol/liter in groups 1 and 2 (p < 0.0005), respectively; low density lipoprotein (LDL) cholesterol levels were 3.2 +/- 0.8 and 4.9 +/- 0.7 mmol/liter (p < 0.0005); high density lipoprotein (HDL) cholesterol levels were 1.1 +/- 0.3 and 1.0 +/- 0.4 mmol/liter (p = NS); and triglyceride levels were 1.8 +/- 1.3 and 3.0 +/- 1.8 mmol/liter (p < 0.005). Groups 1 and 2 did not differ with regardto MBF at rest (0.87 +/- 0.14 vs. 0.84 +/- 0.14), MBF during adenosine (3.63 +/- 1.02 vs. 3.30 +/- 0.86) or CFR (4.23 +/- 1.29 vs. 3.95 +/- 0.93). A significant but weak correlation was found between CFR and HDL in group 1 (r = 0.29, p < 0.05), but not in group 2. In contrast, a significant inversecorrelation between LDL and CFR was found in group 2 (r = -0.61, p < 0.05), but not in group 1. CONCLUSION Low density lipoprotein cholesterol but not TC correlated inversely with CFR in hypercholesterolemic subjects. Thus, LDL-induced coronary microvascular dysfunction could play an important role in the pathogenesis of coronary artery disease and its complications. (J Am Coil Cardiol 2000;36:103-9) (C) 2000 by the American College of Cardiology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 05:11:38