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Titolo:
EFFECTS OF TELENZEPINE AND L-364,718 ON CANINE PANCREATIC-SECRETION BEFORE AND AFTER VAGOTOMY
Autore:
NIEBERGALLROTH E; TEYSSEN S; WETZEL D; HARTEL M; BEGLINGER C; RIEPL RL; SINGER MV;
Indirizzi:
UNIV HEIDELBERG HOSP,DEPT MED GASTROENTEROL 4,THEODOR KUTZER UFER D-68135 MANNHEIM GERMANY UNIV HEIDELBERG HOSP,DEPT MED GASTROENTEROL 4 D-68135 MANNHEIM GERMANY UNIV HEIDELBERG HOSP,DEPT SURG D-68135 MANNHEIM GERMANY UNIV BASEL HOSP,DIV GASTROENTEROL CH-4031 BASEL SWITZERLAND UNIV MUNICH,KLINIKUM INNENSTADT D-80336 MUNICH GERMANY
Titolo Testata:
American journal of physiology: Gastrointestinal and liver physiology
fascicolo: 6, volume: 35, anno: 1997,
pagine: 1550 - 1559
SICI:
0193-1857(1997)35:6<1550:EOTALO>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRADUODENAL TRYPTOPHAN; TRANSPLANTED PANCREAS; PLASMA-CONCENTRATIONS; TRUNCAL VAGOTOMY; ENZYME SECRETION; CHOLECYSTOKININ; ATROPINE; DOGS; STIMULATION; GASTRIN;
Keywords:
TRYPTOPHAN; TRUNCAL VAGOTOMY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
E. Niebergallroth et al., "EFFECTS OF TELENZEPINE AND L-364,718 ON CANINE PANCREATIC-SECRETION BEFORE AND AFTER VAGOTOMY", American journal of physiology: Gastrointestinal and liver physiology, 35(6), 1997, pp. 1550-1559

Abstract

In six conscious dogs we compared the action of the M-1-receptor antagonist telenzepine (20.25-81.0 nmol.kg(-1).h(-1)), the cholecystokinin(CCK) antagonist L-364,718 (0.025-0.1 mg.kg(-1).h(-1)), and combinations of both on the pancreatic secretory response to intraduodenal tryptophan, given against a secretin background before and after truncal vagotomy. Before vagotomy, the higher doses of telenzepine and of L-364,718 significantly (P < 0.05) decreased the protein response to tryptophan by up to 97%. After vagotomy, all doses of L-364,718 abolished the protein response, whereas telenzepine had no further effect. Before and after vagotomy, all combinations abolished the protein response. The plasma CCK-like immunoreactivity basally, during secretin, and in response to tryptophan was not altered by vagotomy, telenzepine, and/orL-364,718. These findings indicate that in dogs I)potentiation existsbetween M-1 receptors and CCK for stimulation of the pancreatic enzyme response to intraduodenal tryptophan, 2) the cholinergic fibers of the enteropancreatic reflex activated by tryptophan run within the vagus nerves and end at least in part on M-1 receptors, 3) CCK acts in part independently of the vagal nerves, and 4) the CCK release by intestinal tryptophan is not influenced by vagotomy, telenzepine, and/or L-364,718.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 01:46:14