Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
UV-B-induced generation of free radicals in blood platelets
Autore:
Bednarska, K; Wachowicz, B; Buczynski, A;
Indirizzi:
Univ Lodz, Dept Gen Biochem, PL-90237 Lodz, Poland Univ Lodz Lodz PolandPL-90237 , Dept Gen Biochem, PL-90237 Lodz, Poland Mil Sch Med, Dept Prevent Med, Lodz, Poland Mil Sch Med Lodz PolandMil Sch Med, Dept Prevent Med, Lodz, Poland
Titolo Testata:
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
fascicolo: 2-3, volume: 55, anno: 2000,
pagine: 109 - 112
SICI:
1011-1344(200004/05)55:2-3<109:UGOFRI>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACTIVATION; 3-KINASE;
Keywords:
UV-B; blood platelets; chemiluminescence; free radicals;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Bednarska, K Univ Lodz, Dept Gen Biochem, Banacha 12-16, PL-90237 Lodz, Poland Univ Lodz Banacha 12-16 Lodz Poland PL-90237 37 Lodz, Poland
Citazione:
K. Bednarska et al., "UV-B-induced generation of free radicals in blood platelets", J PHOTOCH B, 55(2-3), 2000, pp. 109-112

Abstract

W-B irradiation of blood-platelet concentrates is used in transfusion practice to prevent the development of post-transfusion alloimmunization and inactivate viruses and bacteria in the concentrates. W-B radiation may affectthe blood-platelet metabolism and function; therefore we have investigatedthe effect of W-B irradiation on free radical production in blood platelets. Our results show that exposure of pig blood platelets to W-B radiation (0.36 and 1.08 J/cm(2)) induces the generation of free radicals measured by the chemiluminescence method (respectively 28 and 148.6% above the control). The superoxide radical level after UV-B irradiation measured by the cytochrome c reduction method shows only a slight increase (p > 0.05). Free radical generation induced by UV-B radiation is dependent partly on blood-platelet activation and enzymatic pathways, since we have shown that wortmannin,an inhibitor of phosphatidylinositide 3-kinase, reduces the level of radicals formed in blood platelets after W-B irradiation. This indicates that free radicals generated in blood platelets after stimulation by UV-B radiation are involved in platelet activation and metabolism of platelet polyphosphoinositides. (C) 2000 Elsevier Science S.A. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/02/20 alle ore 15:32:45