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Titolo:
The colony-stimulating factors and collagen-induced arthritis: exacerbation of disease by M-CSF and G-CSF and requirement for endogenous M-CSF
Autore:
Campbell, IK; Rich, MJ; Bischof, RJ; Hamilton, JA;
Indirizzi:
Univ Melbourne, Royal Melbourne Hosp, Dept Med, Inflammat Res Ctr, Parkville, Vic, Australia Univ Melbourne Parkville Vic Australia es Ctr, Parkville, Vic, Australia
Titolo Testata:
JOURNAL OF LEUKOCYTE BIOLOGY
fascicolo: 1, volume: 68, anno: 2000,
pagine: 144 - 150
SICI:
0741-5400(200007)68:1<144:TCFACA>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC INFLAMMATORY ARTHRITIS; TUMOR-NECROSIS-FACTOR; ACTIVE RHEUMATOID-ARTHRITIS; HUMAN ARTICULAR-CARTILAGE; FELTYS-SYNDROME; GENE-EXPRESSION; DENDRITIC CELLS; SYNOVIAL FIBROBLASTS; PROGENITOR CELLS; FACTOR-ALPHA;
Keywords:
rheumatoid arthritis; hematopoiesis; cytokines; inflammatory mediators; in vivo animal models;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Campbell, IK PO Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Div Autoimmun &Transplantat, Reid Rheumatol Lab, Melbourne, Vic 3050, Australia PO Royal Melbourne Hosp Melbourne Vic Australia 3050 stralia
Citazione:
I.K. Campbell et al., "The colony-stimulating factors and collagen-induced arthritis: exacerbation of disease by M-CSF and G-CSF and requirement for endogenous M-CSF", J LEUK BIOL, 68(1), 2000, pp. 144-150

Abstract

There is increasing evidence that the colony-stimulating factors (CSFs) may play a part in chronic inflammatory autoimmune diseases, such as rheumatoid arthritis (RA). We examined the involvement of macrophage CSF (M-CSF or CSF-1) and granulocyte CSF (G-CSF) in collagen-induced arthritis (CIA), a murine model of EW, Daily injections of M-CSF or G-CSF, 20-24 days postprimary immunization with type II collagen, exacerbated disease symptoms in suboptimally immunized DBA/1 mice. Support for the involvement of endogenous M-CSF in CIA was obtained by studies in which neutralizing monoclonal antibody reduced the severity of established CIA and also by studies showing the resistance of M-CSF-deficient op/op mice to CIA induction, These studies show that M-CSF and G-CSF can be proinflammatory in CIA and provide evidence that macroghage- and granulocyte-lineage tells can exacerbate CIA. Our results also show that M-CSF-dependent cells are essential for CIA development, suggesting M-CSF may be a suitable target for therapeutic intervention in RA.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 06:55:01