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Titolo:
Vascular endothelial cells provide T cells with costimulatory signals via the OX40/gp34 system
Autore:
Kunitomi, A; Hori, T; Imura, A; Uchiyama, T;
Indirizzi:
Kyoto Univ, Grad Sch Med, Dept Hematol Oncol, Kyoto 6068507, Japan Kyoto Univ Kyoto Japan 6068507 Dept Hematol Oncol, Kyoto 6068507, Japan Kyoto Univ, Grad Sch Med, Dept Tumor Biol, Kyoto 6068507, Japan Kyoto Univ Kyoto Japan 6068507 ed, Dept Tumor Biol, Kyoto 6068507, Japan
Titolo Testata:
JOURNAL OF LEUKOCYTE BIOLOGY
fascicolo: 1, volume: 68, anno: 2000,
pagine: 111 - 118
SICI:
0741-5400(200007)68:1<111:VECPTC>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; NF-KAPPA-B; I HTLV-I; ADHESION MOLECULE-1; FACTOR RECEPTOR; LYMPHOCYTES-T; OX40 LIGAND; ACTIVATION; LEUKEMIA; ANTIGEN;
Keywords:
endothelial biology; T lymphocytes; costimulation; TNF receptor family;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Hori, T Kyoto Univ, Grad Sch Med, Dept Hematol Oncol, 54 Shogoin Kawaracho, Kyoto 6068507, Japan Kyoto Univ 54 Shogoin Kawaracho Kyoto Japan 6068507068507, Japan
Citazione:
A. Kunitomi et al., "Vascular endothelial cells provide T cells with costimulatory signals via the OX40/gp34 system", J LEUK BIOL, 68(1), 2000, pp. 111-118

Abstract

We investigated whether gp34, the ligand of OX40, expressed on EC is involved in costimulation of T cells. Normal CD4(+) T cells were stimulated withanti-CD3-coated beads, phytohemagglutinin (PHA), or concanavalin A (Con A)in the presence or absence of irradiated human umbilical vein endothelial cells (HUVEC). Stimulation of T cells with each of these mitogens results in significant T-cell proliferation only re-hen HUVEC were present, and thisproliferation was inhibited markedly by anti-OX40 or anti-gp34 monoclonal antibody (mAb). T cells cultured with HUVEC produced more interleukin (IL)-2 than those cultured without HUVEC, The addition of anti-IL-2R alpha chainand anti-IL-2R beta chain mAbs abolished the costimulatory effects of HUVEC. Thus, the augmentation of T-cell proliferation appears to he attributable to increased IL-2 production, These results suggest that gp34 expressed on HUVEC plays a role in potentiation of T-cell immune response by providingOX40(+) T cells with costimulatory signals.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 20:22:41