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Titolo:
Engagement of CD153 (CD30 ligand) by CD30(+) T cells inhibits class switchDNA recombination and antibody production in human IgD(+) IgM(+) B cells
Autore:
Cerutti, A; Schaffer, A; Goodwin, RG; Shah, S; Zan, H; Ely, S; Casali, P;
Indirizzi:
Cornell Univ, Weill Med Coll, Dept Pathol, Div Mol Immunol, New York, NY 10021 USA Cornell Univ New York NY USA 10021 iv Mol Immunol, New York, NY 10021 USA Cornell Univ, Weill Grad Sch Med Sci, Program Immunol, New York, NY 10021 USA Cornell Univ New York NY USA 10021 rogram Immunol, New York, NY 10021 USA Immunex Corp, Seattle, WA 98101 USA Immunex Corp Seattle WA USA 98101Immunex Corp, Seattle, WA 98101 USA
Titolo Testata:
JOURNAL OF IMMUNOLOGY
fascicolo: 2, volume: 165, anno: 2000,
pagine: 786 - 794
SICI:
0022-1767(20000715)165:2<786:EOC(LB>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
NF-KAPPA-B; CD40 LIGAND; OX40 LIGAND; GERMINAL-CENTERS; SOMATIC MUTATION; FAMILY PROTEINS; DENDRITIC CELLS; VARIANT CD30; HUMAN TONSIL; RECEPTOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
72
Recensione:
Indirizzi per estratti:
Indirizzo: Cerutti, A Cornell Univ, Weill Med Coll, Dept Pathol, Div Mol Immunol, NewYork, NY 10021 USA Cornell Univ New York NY USA 10021 nol, New York, NY 10021 USA
Citazione:
A. Cerutti et al., "Engagement of CD153 (CD30 ligand) by CD30(+) T cells inhibits class switchDNA recombination and antibody production in human IgD(+) IgM(+) B cells", J IMMUNOL, 165(2), 2000, pp. 786-794

Abstract

CD153 (CD30 ligand) is a member of the TNF ligand/cytokine family expressed on the surface of human B cells, Upon exposure to IL-4, a critical Ig class switch-inducing cytokine, Ag-activated T cells express CD30, the CD153 receptor. The observation that dysregulated IgG, IgA, and/or IgE production is often associated with up-regulation of T cell CD30 prompted us to test the hypothesis that engagement of B cell CD153 by T cell CD30 modulates Ig class switching. In this study, we show that IgD(+) IgM(+) B cells up-regulate CD153 in the presence of CD154 (CD40 ligand), IL-4, and B cell Ag receptor engagement. In these cells, CD153 engagement by an agonistic anti-CD153 mAb or T cell CD30 inhibits S mu->S gamma, S mu->S alpha, and S mu->S epsilon class switch DNA recombination (CSR), This inhibition is associated withdecreased TNFR-associated factor-2 binding to CD40, decreased NF-KB binding to the CD40-responsive element of the C gamma 3 promoter, decreased I gamma 3-C gamma 3 germline gene transcription, and decreased expression of Ku70, Ku80, DNA protein kinase, switch-associated protein-70, and Msh2 CSR-associated transcripts. In addition, CD153 engagement inhibits IgG, IgA, and IgE production, and this effect is associated with reduced levels of B lymphocyte maturation protein-1 transcripts, and increased binding of B cell-specific activation protein to the Ig 3' enhancer. These findings suggest thatCD30(+) T cells modulate CSR as well as IgG, IgA, and IgE production by inducing reverse signaling through B cell CD153.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/08/20 alle ore 23:27:47