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Titolo:
Ethnic and gender differences in electrocardiographic QT length and QT dispersion in hypertensive subjects
Autore:
Chapman, N; Mayet, J; Ozkor, M; Foale, R; Thom, S; Poulter, N;
Indirizzi:
Univ London Imperial Coll Sci Technol & Med, St Marys Hosp, Sch Med, PeartRose Clin, London W2 1NY, England Univ London Imperial Coll Sci Technol & Med London England W2 1NY ngland Univ London Imperial Coll Sci Technol & Med, St Marys Hosp, Sch Med, Dept Cardiol, London W2 1NY, England Univ London Imperial Coll Sci Technol & Med London England W2 1NY ngland
Titolo Testata:
JOURNAL OF HUMAN HYPERTENSION
fascicolo: 6, volume: 14, anno: 2000,
pagine: 403 - 405
SICI:
0950-9240(200006)14:6<403:EAGDIE>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARDIOVASCULAR MORTALITY; INTERVAL; POPULATION;
Keywords:
ECG; QT; ethnicity; gender;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Chapman, N Univ London Imperial Coll Sci Technol & Med, St Marys Hosp, SchMed, Dept Clin Pharmacol, S Wharf Rd, London W2 1NY, England Univ London Imperial Coll Sci Technol & Med S Wharf Rd London England W2 1NY
Citazione:
N. Chapman et al., "Ethnic and gender differences in electrocardiographic QT length and QT dispersion in hypertensive subjects", J HUM HYPER, 14(6), 2000, pp. 403-405

Abstract

Background: Prolonged QT intervals and/or increased QT dispersion (QT(d)) are associated with various pathological conditions and predict death in healthy individuals. Among hypertensives, QT(d) correlates with blood pressure (BP) and left ventricular mass index (LVMI) and QT intervals are prolonged in those with left ventricular hypertrophy (LVH), In normotensives, heart-rate corrected QT length (QT(c)) is longer in females than males, but QT(d) is greater in males than females. There are few data comparing QT parameters between different ethnic groups and none specifically in hypertensives. Among normotensives, compared with whites, QT(c) is reported to be shorterin African-Americans and longer in Chinese. We looked for ethnic and gender differences in QT parameters in hypertensive subjects. Methods: Untreated hypertensives were selected from a Hypertension Clinic database, Black and white subjects were matched for age, sex, BP and LVMI, Male and female subjects were matched for age, race, BP and the presence orabsence of echocardiographic LVH. Maximum QT intervals (QT(m)), rate-corrected maximum QT intervals (QT(c)) and QT dispersion (QT(d)) were measured or calculated from ECGs, Data are presented as mean +/- s,d. Differences in QT parameters were sought between groups using Student's t-tests,Results: No ethnic or gender differences in QT parameters achieved statistical significance. However there was a tendency for QT(m) and QT(c) to be prolonged in blacks compared with whites (443 +/- 52 vs 421 +/- 47; P = 0.08and 480 +/- 65 vs 463 +/- 40: P = 0.24 respectively), and for QTc to be prolonged in females compared with males (479 +/- 52 vs 461 +/- 45 ms; P = 0.13). Conclusion: In small groups of matched hypertensives, no ethnic or gender differences in QT parameters achieved statistical significance. However, similar to findings in normotensives, QT(c) tended to be longer in hypertensive females than males. In hypertensives, we failed to confirm the finding that QT(c) is shorter in blacks than whites, as seen in US normotensives. Whether this represents a difference between hypertensives and normotensives,or between US and UK blacks requires further investigation. Whether the prognostic significance of QT parameters in hypertensives differs between different gender and ethnic groups needs to be established from prospective studies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 15:56:09