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Titolo:
A B cell superantigen-induced persistent "Hole" in the B-1 repertoire
Autore:
Silverman, GJ; Cary, SP; Dwyer, DC; Luo, L; Wagenknecht, R; Curtiss, AE;
Indirizzi:
Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 pt Med, La Jolla, CA 92093 USA
Titolo Testata:
JOURNAL OF EXPERIMENTAL MEDICINE
fascicolo: 1, volume: 192, anno: 2000,
pagine: 87 - 98
SICI:
0022-1007(20000703)192:1<87:ABCSP">2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
STAPHYLOCOCCAL PROTEIN-A; ANTIPHOSPHORYLCHOLINE ANTIBODIES; POSITIVE SELECTION; IMMUNE-RESPONSE; CLONAL NATURE; PHOSPHORYLCHOLINE; BINDING; ANTIGEN; MICE; LYMPHOCYTES;
Keywords:
tolerance; repertoire; clonal selection; immunoglobulin genes; host immunity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Silverman, GJ Univ Calif San Diego, Dept Med, 9500 Gilman Dr, La Jolla, CA92093 USA Univ Calif San Diego 9500 Gilman Dr La Jolla CA USA 92093 SA
Citazione:
G.J. Silverman et al., "A B cell superantigen-induced persistent "Hole" in the B-1 repertoire", J EXP MED, 192(1), 2000, pp. 87-98

Abstract

The bacterial toxin protein A from Staphylococcus aureus (SPA) interacts with B cell antigen receptors encoded by variable region heavy chain (V-H) clan III gents via a V region framework surface that has been highly conserved during the evolution of the adaptive immune system. We have investigatedthe consequences of exposure to this prototypic B cell superantigen, and found that treatment of neonates or adults induces a T cell-independent deletion of a large supra-clonal set of susceptible B cells that includes dan III/V-H S107 family-expressing lymphocytes. III studies of different SpA forms, the magnitude of the induced deletion directly cell-elated with the V-H-specific binding affinity/avidity. Upon cessation of SpA exposure, the representation of conventional splenic (B-2 subset) lymphocytes normalized; however, we found that the V, family-restricted deficit of peritoneal B-1 cells persisted, SpA treatment also induced a persistent loss of splenic S107-mu transcripts, with a loss of certain natural antibodies and specific tolerance to phosphorylcholine immunogens that normally recruit protective antimicrobial responses dominated by the S107-expressing B-1 clone, T15. These studies illustrate how a B cell super-antigen call exploit a primordial Achilles heel in the immune system, for which B-l cells, an important source of natural antibodies and host immune responses, have special susceptibility.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 20:28:57