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Titolo:
A calorimetric study of the influence of temperature on the self-association of amphiphilic antidepressant drugs in aqueous solution
Autore:
Attwood, D; Boitard, E; Dubes, JP; Tachoire, H;
Indirizzi:
Univ Manchester, Sch Pharm & Pharmaceut Sci, Manchester M13 9PL, Lancs, England Univ Manchester Manchester Lancs England M13 9PL M13 9PL, Lancs, England Univ Aix Marseille 1, Ctr Microcalorimetrie & Thermochim, Lab Thermochim, F-13331 Marseille 3, France Univ Aix Marseille 1 Marseille France 3 him, F-13331 Marseille 3, France
Titolo Testata:
JOURNAL OF COLLOID AND INTERFACE SCIENCE
fascicolo: 2, volume: 227, anno: 2000,
pagine: 356 - 362
SICI:
0021-9797(20000715)227:2<356:ACSOTI>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
IONIC SURFACTANT SOLUTIONS; APPARENT MOLAR ENTHALPIES; THERMODYNAMIC PROPERTIES; ELECTROLYTE SOLUTIONS; VOLUMES; MODEL;
Keywords:
calorimetry; micelles; apparent molar enthalpy; mass action theory; antidepressant drugs;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Attwood, D Univ Manchester, Sch Pharm & Pharmaceut Sci, Manchester M13 9PL, Lancs, England Univ Manchester Manchester Lancs England M13 9PL ancs, England
Citazione:
D. Attwood et al., "A calorimetric study of the influence of temperature on the self-association of amphiphilic antidepressant drugs in aqueous solution", J COLL I SC, 227(2), 2000, pp. 356-362

Abstract

Relative apparent molar enthalpies have been determined as a function of concentration (0.0001 to 0.2 mol kg(-1)) by heat conduction calorimetry for aqueous solutions of the structurally related antidepressant drugs imipramine and domipramine in water over the temperature range 288 to 308 K. Critical concentrations determined from inflections in these plots for both drugshad minimum values at 298 K. The concentration dependence of the relative apparent molar enthalpy could be quantitatively described using a mass action model of association based on the Guggenheim equations for the activity coefficients of mixed electrolytes, Derived values of the monomer-counterion interaction coefficient for imipramine became increasingly negative with an increase in temperature over the temperature range 293 to 303 K, indicative of an increasing degree of premicellar association. In contrast, negative monomer-counterion interaction coefficients were obtained far domipramine at only 303 and 308 K, suggesting an absence of premicellar association at lower temperatures. Values derived for the molar enthalpy of micellization of both drugs from the mass action model indicate an increasingly exothermic process with increase in temperature; positive values at 288 and 293 iiarise from hydrophobic interactions while the negative values at higher temperatures suggest the importance of London dispersion interactions as the major driving force for aggregation. (C) 2000 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 15:11:36