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Titolo:
Use of prevalence and incidence measures to describe age-related prescribing of antidepressants with and without anticholinergic effects
Autore:
van Eijk, MEC; Bahri, P; Dekker, G; Herings, RMC; Porsius, A; Avorn, J; de Boer, A;
Indirizzi:
Univ Utrecht, Fac Pharm, Inst Pharmaceut Sci, Dept Pharmacoepidemiol & Pharmacotherapy, NL-3508 TB Utrecht, Netherlands Univ Utrecht Utrecht Netherlands NL-3508 TB 3508 TB Utrecht, Netherlands OZ Zorgverzekeringen, Breda, Netherlands OZ Zorgverzekeringen Breda Netherlands erzekeringen, Breda, Netherlands Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Med,Div Pharmacoepidemiol, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 Pharmacoepidemiol, Boston, MA 02115 USA
Titolo Testata:
JOURNAL OF CLINICAL EPIDEMIOLOGY
fascicolo: 6, volume: 53, anno: 2000,
pagine: 645 - 651
SICI:
0895-4356(200006)53:6<645:UOPAIM>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
INAPPROPRIATE MEDICATION USE; DRUG; DEPRESSION; GUIDE;
Keywords:
antidepressive agents; aged; drug utilization (review); pharmacoepidemiology; prevalence, incidence;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: de Boer, A Univ Utrecht, Fac Pharm, Inst Pharmaceut Sci, Dept Pharmacoepidemiol & Pharmacotherapy, POB 80082, NL-3508 TB Utrecht, Netherlands Univ Utrecht POB 80082 Utrecht Netherlands NL-3508 TB herlands
Citazione:
M.E.C. van Eijk et al., "Use of prevalence and incidence measures to describe age-related prescribing of antidepressants with and without anticholinergic effects", J CLIN EPID, 53(6), 2000, pp. 645-651

Abstract

To evaluate whether physicians avoid prescribing highly anticholinergic antidepressants (AAD) in the elderly, a population-based retrospectively dataanalysis was performed using databases from a Dutch health insurance company. Data collected on approximately 240,000 persons covered the period from1 July 1993 to 1 January 1996. The prevalence and the incidence (number ofnew starters) of antidepressant use was measured over 1994 and 1995. Use of AAD was proportionally higher in the elderly in terms of both prevalence and incidence rates; the ratio of starters of AAD versus starters of non-AAD in 1994 increased steadily with age (from 0.54 in the age group 20-29 to 1.15 in the age group 60-69). In 1995 these incidence ratios decreased (0.41 to 0.99, respectively); however, the decrease was higher in the younger age groups. The data indicate that in the population studied, physicians do not refrain from prescribing highly anticholinergic agents to older patients despite their potential adverse drug reactions in this age group. This study also indicates that prevalence and incidence rates can be extracted from reimbursement data and give insight into actual prescribing practices. (C) 2000 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 22:03:00