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Titolo:
Apoptotic signaling through the beta-adrenergic receptor - A new G(s) effector pathways
Autore:
Gu, CH; Ma, YC; Benjamin, J; Littman, D; Chao, MV; Huang, XY;
Indirizzi:
NYU, Med Ctr, Skirball Inst, New York, NY 10016 USA NYU New York NY USA 10016 Med Ctr, Skirball Inst, New York, NY 10016 USA Cornell Univ, Coll Med, Grad Program Cell Biol & Genet, New York, NY 10021USA Cornell Univ New York NY USA 10021 ll Biol & Genet, New York, NY 10021USA Cornell Univ, Coll Med, Grad Program Physiol Biophys & Mol Med, New York, NY 10021 USA Cornell Univ New York NY USA 10021 phys & Mol Med, New York, NY 10021 USA Cornell Univ, Coll Med, Dept Physiol, New York, NY 10021 USA Cornell UnivNew York NY USA 10021 , Dept Physiol, New York, NY 10021 USA
Titolo Testata:
JOURNAL OF BIOLOGICAL CHEMISTRY
fascicolo: 27, volume: 275, anno: 2000,
pagine: 20726 - 20733
SICI:
0021-9258(20000707)275:27<20726:ASTTBR>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-COUPLED RECEPTORS; MOUSE LYMPHOMA-CELLS; TYROSINE-KINASE; ADENYLATE-CYCLASE; ALPHA-SUBUNIT; CYCLIC-AMP; GS-ALPHA; DNA FRAGMENTATION; TRANSGENIC MICE; T-CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Chao, MV NYU, Med Ctr, Skirball Inst, New York, NY 10016 USA NYU New YorkNY USA 10016 Skirball Inst, New York, NY 10016 USA
Citazione:
C.H. Gu et al., "Apoptotic signaling through the beta-adrenergic receptor - A new G(s) effector pathways", J BIOL CHEM, 275(27), 2000, pp. 20726-20733

Abstract

Stimulation of beta-adrenergic receptor normally results in signaling by the heterotrimeric G protein G(s), leading to the activation of adenylyl cyclase, production of cAMP, and activation of cAMP-dependent protein kinase (PKA), Here we report that cell death of thymocytes can be induced after stimulation of beta-adrenergic receptor, or by addition of exogenous cAMP. Apoptotic cell death in both cases was observed with the appearance of terminal deoxynucleotidyl transferase-mediated UTP end labeling reactivity and theactivation of caspase-3 in S49 T cells. Using thymocytes deficient in either G alpha(s) or PKA, we find that engagement of beta-adrenergic receptors initiated a G alpha(s)-dependent, PKA-independent pathway leading to apoptosis, This alternative pathway involves Src family tyrosine kinase Lck. Furthermore, we show that Lck protein kinase activity can be directly stimulated by purified G alpha(s). Our data reveal a new signaling pathway for G alpha(s), distinct from the classical PKA pathway, that accounts for the apoptotic action of beta-adrenergic receptors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 09:20:00