Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Adenovirus E1A down-regulates LMP2 transcription by interfering with the binding of Stat1 to IRF1
Autore:
Chatterjee-Kishore, M; van den Akker, F; Stark, GR;
Indirizzi:
Cleveland Clin Fdn, Lerner Res Inst, Dept Biol Mol, Cleveland, OH 44145 USA Cleveland Clin Fdn Cleveland OH USA 44145 ol Mol, Cleveland, OH 44145 USA
Titolo Testata:
JOURNAL OF BIOLOGICAL CHEMISTRY
fascicolo: 27, volume: 275, anno: 2000,
pagine: 20406 - 20411
SICI:
0021-9258(20000707)275:27<20406:AEDLTB>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
ONCOGENIC ADENOVIRUS-12; SIGNAL TRANSDUCER; TRANSFORMED-CELLS; GENE-EXPRESSION; AD12 E1A; COMPLEX; PROMOTER; PROTEINS; DOMAINS; IDENTIFICATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Stark, GR Cleveland Clin Fdn, Lerner Res Inst, Dept Biol Mol, 9500 Euclid Ave, Cleveland, OH 44145 USA Cleveland Clin Fdn 9500 Euclid Ave Cleveland OH USA 44145 45 USA
Citazione:
M. Chatterjee-Kishore et al., "Adenovirus E1A down-regulates LMP2 transcription by interfering with the binding of Stat1 to IRF1", J BIOL CHEM, 275(27), 2000, pp. 20406-20411

Abstract

The LMP2 gene, which encodes a protein required for efficient presentationof viral antigens, requires both unphosphorylated Stat1 and IRF1 for basalexpression. LMP2 expression is down-regulated by the adenovirus protein E1A, which binds to Stat1 and CBP/p300, and by the mutant E1A protein RG2, which binds to Stat1 but not to CBP/p300, but not by the mutant protein Delta2-36, which does not bind to either Stat1 or CBP/p300, Stat1 and IRF1 associate in untreated cells and bind as a complex to the overlapping ICS-2/GASelement of the LMP2 promoter. E1A interferes with the formation of this complex by occupying domains of Stat1 that bind to IRF1. These results revealhow adenovirus infection attenuates LMP2 expression, thereby interfering with the presentation of viral antigens.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 21:15:14