Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Granulocyte colony-stimulating factor and lineage-independent modulation of VLA-4 expression on circulating CD34(+) cells
Autore:
Yano, T; Katayama, Y; Sunami, K; Ishimaru, F; Shinagawa, K; Ikeda, K; Omoto, E; Niiya, K; Harada, M;
Indirizzi:
Okayama Univ, Sch Med, Dept Med 2, Okayama 7008558, Japan Okayama Univ Okayama Japan 7008558 d, Dept Med 2, Okayama 7008558, Japan
Titolo Testata:
INTERNATIONAL JOURNAL OF HEMATOLOGY
fascicolo: 4, volume: 71, anno: 2000,
pagine: 328 - 333
SICI:
0925-5710(200006)71:4<328:GCFALM>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEMATOPOIETIC PROGENITOR CELLS; PERIPHERAL-BLOOD; BONE-MARROW; G-CSF; ADHESION MOLECULES; TRANSENDOTHELIAL MIGRATION; LEUKAPHERESIS PRODUCTS; CORD-BLOOD; L-SELECTIN; MOBILIZATION;
Keywords:
G-CSF; mobilization; VLA-4;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Yano, T Okayama Univ, Sch Med, Dept Med 2, 2-5-1 Shikata Cho, Okayama 7008558, Japan Okayama Univ 2-5-1 Shikata Cho Okayama Japan 7008558 08558, Japan
Citazione:
T. Yano et al., "Granulocyte colony-stimulating factor and lineage-independent modulation of VLA-4 expression on circulating CD34(+) cells", INT J HEMAT, 71(4), 2000, pp. 328-333

Abstract

Although the use of allogeneic transplants of peripheral blood stem/progenitor cells (PBSCs) is increasing, the precise mechanism of PBSC mobilization has not yet been fully clarified. We examined the expression of some adhesion molecules on CD34(+) cells from steady-state bone marrow (BM), granulocyte colony-stimulating factor (G-CSF)-mobilized PBSCs, and cytotoxic drugsplus G-CSF-mobilized PBSCs. Irrespective of mobilization method, very lateantigen (VLA)-4 expression on circulating CD34(+) cells was significantly lower than on steady-state BM CD34(+) cells. To elucidate the influence of lineage commitment on VLA-4 expression of circulating CD34(+) cells, we analyzed VLA-4 expression on different subsets of CD34(+) cells with or without CD33, CD38, CD5, or CD10 antigens, or Glycophorin A in G-CSF-mobilized PBSCs and steady-state BM from related donors, using 3-color flow cytometry VLA-4 on circulating CD34(+) subsets was less expressed than on each corresponding subset of steady-state BM CD34(+) cells. Furthermore, VLA-4 positiverates showed no significant difference among the CD34(+) subsets. Finally,the data comparing CD34(+) cells from steady-state and G-CSF-mobilized PBSCs revealed no differences in terms of VLA-4 expression. These data suggestthat reduced expression of VLA-4 may be a result of peripheralization of CD34(+) cells from bone marrow, which occurs in a G-CSF- and lineage-independent fashion. Int J Hematol. 2000;71:328-333. (C) 2000 The Japanese Societyof Hematology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 18:22:51