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Titolo:
Hitchhiking under positive Darwinian selection
Autore:
Fay, JC; Wu, CI;
Indirizzi:
Univ Chicago, Dept Ecol & Evolut, Chicago, IL 60637 USA Univ Chicago Chicago IL USA 60637 pt Ecol & Evolut, Chicago, IL 60637 USA Univ Chicago, Comm Genet, Chicago, IL 60637 USA Univ Chicago Chicago IL USA 60637 cago, Comm Genet, Chicago, IL 60637 USA
Titolo Testata:
GENETICS
fascicolo: 3, volume: 155, anno: 2000,
pagine: 1405 - 1413
SICI:
0016-6731(200007)155:3<1405:HUPDS>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
DROSOPHILA-ANANASSAE POPULATIONS; MELANOGASTER SPECIES COMPLEX; NEUTRAL MOLECULAR VARIATION; NUCLEAR-DNA VARIATION; X-LINKED LOCI; BACKGROUND SELECTION; CENTROMERIC REGION; STATISTICAL TESTS; NATURAL-POPULATIONS; GENETIC HITCHHIKING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Wu, CI Univ Chicago, Dept Ecol & Evolut, 1101 E 57th St, Chicago, IL 60637USA Univ Chicago 1101 E 57th St Chicago IL USA 60637 cago, IL 60637 USA
Citazione:
J.C. Fay e C.I. Wu, "Hitchhiking under positive Darwinian selection", GENETICS, 155(3), 2000, pp. 1405-1413

Abstract

Positive selection can be inferred from its effect on linked neutral variation. In the restrictive case when there is no recombination, all linked variation is removed. If recombination is present but rare, both deterministic and stochastic models of positive selection show that linked variation hitchhikes to either low or high frequencies. While the frequency distribution of variation can be influenced by a number of evolutionary processes, an excess of derived variants at high frequency is a unique pattern produced by hitchhiking: (derived refers to the nonancestral state as determined froman outgroup). We adopt a statistic, H, to measure an excess of high compared to intermediate frequency variants. Only a few high-frequency variants are needed to detect hitchhiking since not many are expected under neutrality. This is of particular utility in regions of low recombination where there is not much variation and in regions of normal or high recombination, where the hitchhiking effect call be limited to a small (<1 kb) region. Application of the H test to published surveys of Drosophila variation reveals anexcess of high frequency variants that are likely to have been influenced by positive selection.

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Documento generato il 02/12/20 alle ore 18:20:20