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Titolo:
Nucleotide polymorphism at the RpII215 gene in Drosophila subobscura: Weakselection on synonymous mutations
Autore:
Llopart, A; Aguade, M;
Indirizzi:
Univ Barcelona, Fac Biol, Dept Genet, E-08071 Barcelona, Spain Univ Barcelona Barcelona Spain E-08071 t Genet, E-08071 Barcelona, Spain
Titolo Testata:
GENETICS
fascicolo: 3, volume: 155, anno: 2000,
pagine: 1245 - 1252
SICI:
0016-6731(200007)155:3<1245:NPATRG>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
CODON USAGE; NATURAL-SELECTION; DNA POLYMORPHISM; CODING REGION; SILENT SITES; EVOLUTION; DIVERGENCE; BIAS; RECOMBINATION; SUBSTITUTIONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Llopart, A Univ Chicago, Dept Ecol & Evolut, 1101 E 57th St, Chicago, IL 60637 USA Univ Chicago 1101 E 57th St Chicago IL USA 60637 , IL 60637 USA
Citazione:
A. Llopart e M. Aguade, "Nucleotide polymorphism at the RpII215 gene in Drosophila subobscura: Weakselection on synonymous mutations", GENETICS, 155(3), 2000, pp. 1245-1252

Abstract

Nucleotide variation in an 8.1-kb fragment encompassing the RpII215 gene, which encodes the largest subunit of die RNA polymerase II complex, is analyzed in a sample of II chromosomes from a natural population of Drosophila subobscura. No amino acid polymorphism was detected among the 157 segregating sites. The observed numbers of preferred and unpreferred derived synonymous mutations can be explained by neutral mutational processes. In contrast, preferred mutations segregate at significantly higher frequency than unpreferred mutations, suggesting the action of natural selection. The polymorphism to divergence ratio is different for preferred and unpreferred changes, in agreement with their beneficial and deleterious effects on fitness, respectively. Preferred and unpreferred codons are nonrandomly distributed inthe RpII215 gene:, leading to a heterogeneous distribution of polymorphic to fixed synonymous differences across this coding region. This intragenic variation of the polymorphism/divergence ratio cannot be explained by different patterns of gene expression, mutation, or recombination rates, and therefore it indicates that selection coefficients for synonymous mutations call vary extensively across a coding region. The application of nucleotide composition stationarity tests in coding and flanking noncoding regions, assumed to behave neutrally, allows the detection of the action of natural selection when stationarity holds in the noncoding region.

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Documento generato il 04/12/20 alle ore 13:28:09