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Titolo:
Orphanin FQ, but not dynorphin A, accelerates colonic transit in rats
Autore:
Takahashi, T; Mizuta, Y; Owyang, C;
Indirizzi:
Univ Michigan, Div Gastroenterol, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 stroenterol, Ann Arbor, MI 48109 USA
Titolo Testata:
GASTROENTEROLOGY
fascicolo: 1, volume: 119, anno: 2000,
pagine: 71 - 79
SICI:
0016-5085(200007)119:1<71:OFBNDA>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR GENE FAMILY; OPIOID RECEPTOR; NOCICEPTIN RECEPTOR; ENDOGENOUS LIGAND; OPIATE RECEPTORS; CIRCULAR MUSCLE; ORL1 RECEPTOR; NITRIC-OXIDE; CLONING; AGONIST;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Owyang, C Univ Michigan, Div Gastroenterol, 3912 Taubman Ctr, Ann Arbor, MI 48109 USA Univ Michigan 3912 Taubman Ctr Ann Arbor MI USA 48109 48109 USA
Citazione:
T. Takahashi et al., "Orphanin FQ, but not dynorphin A, accelerates colonic transit in rats", GASTROENTY, 119(1), 2000, pp. 71-79

Abstract

Background & Aims: The endogenous opiate receptor-like 1 ligand, orphanin FQ (OFQ), which structurally resembles dynorphin A, has been identified. Weinvestigated the mechanism of action of OFQ in the colon and compared it with that of dynorphin A in vivo, Methods: Colonic contractions were recorded via miniature force transducers implanted on the serosal surface of the rat colon. Results: Intravenous administration of OfQ (0.01-3 nmol/kg) induced contractions in the rat colon in a dose-dependent manner. Colonic contractions induced by OfQ were not affected by extrinsic denervation but abolished by tetrodotoxin, Continuous infusion of OFQ (1 nmol . kg(-1) . min(-1))and dynorphin A (100 nmol . kg(-1) . min(-1)) induced similar phasic contractions in the proximal colon. However, the contractile activity induced bythe 2 peptides differed significantly in the mid and distal colon. Giant contractions induced by OFQ infusion migrated from the mid to distal colon. In contrast, dynorphin A evoked simultaneous contractions throughout the entire colon, which did not migrate aborally. Subcutaneous administration of OFQ (1-3 nmol/kg) accelerated colonic transit, whereas dynorphin A (30-100 nmol/kg) delayed colonic transit, Conclusions: The results show that OFQ accelerates colonic transit by promoting migrating colonic contractions in rats.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 08:55:40