Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Circulating antibodies to human and bovine cornea in human keratoplasty
Autore:
Robert, PY; Adenis, JP; Cogne, M; Drouet, M;
Indirizzi:
CHU Dupuytren, Serv Ophtalmol, F-87042 Limoges, France CHU Dupuytren Limoges France F-87042 Ophtalmol, F-87042 Limoges, France CHU Dupuytren, Lab Immunol Immunogenet, CNRS 118, F-87042 Limoges, France CHU Dupuytren Limoges France F-87042 , CNRS 118, F-87042 Limoges, France Inst Univ France, Paris, France Inst Univ France Paris FranceInst Univ France, Paris, France
Titolo Testata:
EUROPEAN JOURNAL OF OPHTHALMOLOGY
fascicolo: 2, volume: 10, anno: 2000,
pagine: 132 - 136
SICI:
1120-6721(200004/06)10:2<132:CATHAB>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSPLANTATION; EPITHELIUM; PRETRANSPLANT; ANTIGENS;
Keywords:
corneal allograft; ELISA; anti-corneal antibodies; HLA antigens;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: Adenis, JP CHU Dupuytren, Serv Ophtalmol, 2 Av Martin Luther King, F-87042Limoges, France CHU Dupuytren 2 Av Martin Luther King Limoges France F-87042 e
Citazione:
P.Y. Robert et al., "Circulating antibodies to human and bovine cornea in human keratoplasty", EUR J OPTHA, 10(2), 2000, pp. 132-136

Abstract

PURPOSE. TO compare anti-human cornea and anti-bovine cornea serum reactivity in corneal transplantation and pathology. METHODS. We investigated the presence of IgG and IgM antibodies to bovine corneal extract (BCE) and human corneal extract (HCE) by ELISA in 48 healthy adults and in 30 corneal allograft recipients before and after grafting. Baseline levels of antibodies in healthy controls served to establish a positivity threshold. Anti-HLA antibodies were investigated in all patients. RESULTS. Preoperatively, five and one patient were positive respectively for IgG and IgM anti-BCE; one and ten patients were positive for IgG and IgManti-HCE. The presence or absence of antibodies was not modified after grafting, and was not associated with rejection. Anti-HCE of the IgM class were more frequent in patients with keratoconus. Two patients had anti-HLA antibodies. CONCLUSIONS. Antibodies to non-HLA corneal antigens are detectable in corneal allograft recipients. Reactions against bovine and human substrates differ in frequency and class. This reactivity is not modified after grafting or rejection, but is increased in corneal disorders, including keratoconus.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 11:08:10