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Titolo:
Expression patterns of the regulatory proteins G protein-coupled receptor kinase 2 and beta-arrestin 1 during rat postnatal brain development - Effect of hypothyroidism
Autore:
Penela, P; Alvarez-Dolado, M; Munoz, A; Mayor, F;
Indirizzi:
Univ Autonoma Madrid, CSIC, Ctr Biol Mol Severo Ochoa, Dept Biol Mol, E-28049 Madrid, Spain Univ Autonoma Madrid Madrid Spain E-28049 iol Mol, E-28049 Madrid, Spain Univ Autonoma Madrid, CSIC, Inst Invest Biomed, E-28049 Madrid, Spain UnivAutonoma Madrid Madrid Spain E-28049 Biomed, E-28049 Madrid, Spain
Titolo Testata:
EUROPEAN JOURNAL OF BIOCHEMISTRY
fascicolo: 14, volume: 267, anno: 2000,
pagine: 4390 - 4396
SICI:
0014-2956(200007)267:14<4390:EPOTRP>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
THYROID-HORMONE; ADRENERGIC RECEPTORS; PROTEASOME PATHWAY; CEREBRAL-CORTEX; BINDING; DESENSITIZATION; INTERNALIZATION; MECHANISMS; FAMILY;
Keywords:
arrestins; G-protein-coupled receptor kinases; hypothyroidism; postnatal development; receptor regulation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Mayor, F Univ Autonoma Madrid, CSIC, Ctr Biol Mol Severo Ochoa, Dept Biol Mol, E-28049 Madrid, Spain Univ Autonoma Madrid Madrid Spain E-28049 E-28049 Madrid, Spain
Citazione:
P. Penela et al., "Expression patterns of the regulatory proteins G protein-coupled receptor kinase 2 and beta-arrestin 1 during rat postnatal brain development - Effect of hypothyroidism", EUR J BIOCH, 267(14), 2000, pp. 4390-4396

Abstract

G protein-coupled receptor kinase 2 (GRK2) and beta-arrestin 1 are key regulatory proteins that modulate the desensitization and resensitization of awide variety of G protein-coupled receptors (GPCRs) involved in brain functions. In this report, we describe the postnatal developmental profile of the mRNA and protein levels of GRK2 and beta-arrestin 1 in rat brain. The expression levels of GRK2 and beta-arrestin 1 display a marked increase at the second and third week after birth, respectively, consistent with an involvement of these proteins in brain maturation processes. However, the expression attained at birth and during the first postnatal week with respect to adult values (45-70% for GRK2, approximate to 30% for beta-arrestin 1) is relatively high compared to that reported for several GPCRs, indicating the existence of changes in the ratio of receptors to their regulatory proteinsduring brain development. On the other hand, we report that experimental hypothyroidism results in changes in the patterns of expression of GRK2 and beta-arrestin 1 in cerebral cortex, leading to a 25-30% reduction in GRK2 levels at several stages of development. Such changes could help to explain the alterations in GPCR signaling that occur during this pathophysiologicalcondition.

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Documento generato il 08/07/20 alle ore 07:40:32