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Titolo:
Current developments in single photon radiopharmaceuticals for tumor imaging
Autore:
Ozker, K;
Indirizzi:
Med Coll Wisconsin, Milwaukee, WI 53226 USA Med Coll Wisconsin Milwaukee WI USA 53226 consin, Milwaukee, WI 53226 USA
Titolo Testata:
CURRENT PHARMACEUTICAL DESIGN
fascicolo: 11, volume: 6, anno: 2000,
pagine: 1123 - 1126
SICI:
1381-6128(200007)6:11<1123:CDISPR>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
MONOCLONAL-ANTIBODY; IODINE-123-ALPHA-METHYL TYROSINE; GLUCOSE-TRANSPORT; ENDOCRINE TUMORS; PEPTIDE; CANCER; 6-DEOXY-6-IODO-D-GLUCOSE; PHARMACOKINETICS; BIODISTRIBUTION; ADENOCARCINOMAS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Ozker, K Med Coll Wisconsin, 9200 W Wisconsin Ave, Milwaukee, WI 53226 USAMed Coll Wisconsin 9200 W Wisconsin Ave Milwaukee WI USA 53226 SA
Citazione:
K. Ozker, "Current developments in single photon radiopharmaceuticals for tumor imaging", CUR PHARM D, 6(11), 2000, pp. 1123-1126

Abstract

Development of peptides and amino acids labeled with single photon gamma emitters has promoted a large number of investigations in nuclear medicine especially for tumor imaging. Radiolabeled peptides have several advantages over antibodies mainly related to immunogenicity and size. Tumor localization and total body clearance of peptides are more rapid compared to antibodies. Recently, several somatostatin analogues labeled with Tc-99m have been studied by several different investigators. In-111 labeled lanreotide (Mauritus) was reported to be highly successful in localization of neuroendocrine tumors. A synthetic amino acid, alpha methyl tyrosine labeled with I-123 was shown to be transported to tumors by a carrier mediated system. Development of a glucose analog labeled with a single photon emitting radionuclideand meeting the structural requirements for hexokinase reaction and phosphorylation have not yet been possible. However, it has been possible to synthesize chemically stable single photon glucose analogues interacting with glut(s), glucose transporters.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/01/21 alle ore 07:15:04