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Titolo:
Alveolar-capillary membrane dysfunction in chronic heart failure: pathophysiology and therapeutic implications
Autore:
Guazzi, M;
Indirizzi:
Univ Milan, Ist Cardiol, I-20138 Milan, Italy Univ Milan Milan Italy I-20138 Milan, Ist Cardiol, I-20138 Milan, Italy CNR, Ctr Studio Ric Cardiovasc, I-20133 Milan, Italy CNR Milan Italy I-20133 Ctr Studio Ric Cardiovasc, I-20133 Milan, Italy IRCCS, Ctr Cardiol, Milan, Italy IRCCS Milan ItalyIRCCS, Ctr Cardiol, Milan, Italy
Titolo Testata:
CLINICAL SCIENCE
fascicolo: 6, volume: 98, anno: 2000,
pagine: 633 - 641
SICI:
0143-5221(200006)98:6<633:AMDICH>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
LEFT-VENTRICULAR DYSFUNCTION; PULMONARY MICROVASCULAR PERMEABILITY; EXERCISE OXYGEN-UPTAKE; DIFFUSING-CAPACITY; GAS-EXCHANGE; TRANSPLANT RECIPIENTS; LIQUID CLEARANCE; CARBON-MONOXIDE; PEAK EXERCISE; FOLLOW-UP;
Keywords:
gas diffusion; heart failure; pulmonary function;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
73
Recensione:
Indirizzi per estratti:
Indirizzo: Guazzi, M Univ Milan, Ist Cardiol, Via C Parea 4, I-20138 Milan, Italy Univ Milan Via C Parea 4 Milan Italy I-20138 20138 Milan, Italy
Citazione:
M. Guazzi, "Alveolar-capillary membrane dysfunction in chronic heart failure: pathophysiology and therapeutic implications", CLIN SCI, 98(6), 2000, pp. 633-641

Abstract

Chronic heart failure (CHF) disturbs the alveolar-capillary interface and increases the resistance to gas transfer. Alveolar-capillary membrane conductance (D-M) and capillary blood volume (V-c) are subcomponents of the lungdiffusion capacity. Elevation of the capillary pressure causes alveolar-capillary membrane stress failure (i.e. increase in capillary permeability towater and ions, and disruption of local regulatory mechanisms for gas exchange), leading to a decrease in D-M, an increase in V-c and subsequent impairment of diffusion capacity. Renewed recent interest in abnormalities in lung diffusion in patients with CHF has brought about new pathophysiologicalinsights. A significant contribution of the altered gas transfer to the pathogenesis of exercise limitation and ventilatory abnormalities has been reported, and D-M has been identified as the best lung function predictor of oxygen uptake at peak exercise. This review examines the pathophysiologicaland clinical significance of assessing lung diffusion capacity in patientswith CHF.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 14:10:43