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Titolo:
Vascular endothelial growth pattern of endochondral bone graft in the presence of demineralized intramembranous bone matrix - Quantitative analysis
Autore:
Chow, KMC; Rabie, ABM;
Indirizzi:
Univ Hong Kong, Fac Dent, Prince Philip Dent Hosp 2F, Hong Kong, Hong Kong, Peoples R China Univ Hong Kong Hong Kong Hong Kong Peoples R China Kong, Peoples R China Univ Hong Kong, Fac Dent, Hong Kong, Hong Kong, Peoples R China Univ Hong Kong Hong Kong Hong Kong Peoples R China Kong, Peoples R China
Titolo Testata:
CLEFT PALATE-CRANIOFACIAL JOURNAL
fascicolo: 4, volume: 37, anno: 2000,
pagine: 385 - 394
SICI:
1055-6656(200007)37:4<385:VEGPOE>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
BREAST-CANCER; RECONSTRUCTION; INVASION; DEFECTS; TISSUES;
Keywords:
angiogenesis; bone induction; composite endochondral bone/demineralized; intramembranous bone matrix; demineralized bone matrix; EN 7/44; endochondral bone; intramembranous bone;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Rabie, ABM Univ Hong Kong, Fac Dent, Prince Philip Dent Hosp 2F, 34 Hosp Rd, Hong Kong, Hong Kong, Peoples R China Univ Hong Kong 34 Hosp Rd Hong Kong Hong Kong Peoples R China
Citazione:
K.M.C. Chow e A.B.M. Rabie, "Vascular endothelial growth pattern of endochondral bone graft in the presence of demineralized intramembranous bone matrix - Quantitative analysis", CLEF PAL-CR, 37(4), 2000, pp. 385-394

Abstract

Objective: To determine the timely ingrowth of new blood vessels of composite endochondral (EC) bone and demineralized bone matrix (DBM) prepared from intramembranous (IM) origin (EC-DBMIM) and to compare it with EC bone graft alone. Design: Thirty-two rabbits with 32 critical-size (10 x 5 mm), full-thickness bony defects in rabbit parietal bone were divided into two groups: composite EC-DBMIM group-implanted with composite autogenous EC bone and DBMIM; EC bone group-implanted with EC bone alone. Two rabbits from each group were sacrificed 1, 2, 3, 4, 5, 6, 7, and 14 days after grafting. Neovascularization was assessed by immunohistochemical staining with antihuman angiogenesis-related endothelial cell antibodies (EN 7/44). Quantitative analysis ofneovascularization, represented by percentage area of positive immunohistochemical staining, was performed on 320 sections of the experimental groupsby a computer-assisted image analyzer. Results: Positive immunohistochemical staining was first identified on day2 post grafting for the composite EC-DBMIM group in comparison with day 4 in the EC bone graft group. The composite EC-DBMIM bone graft group showed earlier and almost 100% more neovascularization when compared with the EC bone graft group. Conclusion: DBMIM enhances healing and integration of EC bone graft by enhancing vascularization as well as increasing the amount of new blood vessels formed. In clinical cases in which EC autogenous bone is used to graft a large defect such as in cleft palate and craniofacial surgery, DBMIM shouldallow better integration and healing of the EC bone graft to the host bone.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 15:33:43