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Titolo:
Age-related changes in intracranial pressure in rabbits with uncorrected familial coronal suture synostosis
Autore:
Fellows-Mayle, WK; Mooney, MP; Losken, HW; Dechant, J; Cooper, GM; Burrows, AM; Smith, TD; Pollack, IF; Siegel, MI;
Indirizzi:
Univ Pittsburgh, Dept Oral Med & Pathol, Pittsburgh, PA 15261 USA Univ Pittsburgh Pittsburgh PA USA 15261 Pathol, Pittsburgh, PA 15261 USA Univ Pittsburgh, Dept Neurol Surg, Pittsburgh, PA 15260 USA Univ Pittsburgh Pittsburgh PA USA 15260 ol Surg, Pittsburgh, PA 15260 USA Univ Pittsburgh, Dept Anthropol, Pittsburgh, PA 15260 USA Univ PittsburghPittsburgh PA USA 15260 thropol, Pittsburgh, PA 15260 USA Univ Pittsburgh, Dept Plast & Reconstruct Surg, Pittsburgh, PA 15260 USA Univ Pittsburgh Pittsburgh PA USA 15260 ct Surg, Pittsburgh, PA 15260 USA Univ Pittsburgh, Dept Orthodont, Pittsburgh, PA 15260 USA Univ PittsburghPittsburgh PA USA 15260 thodont, Pittsburgh, PA 15260 USA Univ Pittsburgh, Cleft Palate Craniofacial Ctr, Pittsburgh, PA 15260 USA Univ Pittsburgh Pittsburgh PA USA 15260 ial Ctr, Pittsburgh, PA 15260 USA Univ Pittsburgh, Div Plast & Reconstruct Surg, Pittsburgh, PA 15260 USA Univ Pittsburgh Pittsburgh PA USA 15260 ct Surg, Pittsburgh, PA 15260 USA Childrens Hosp, Pittsburgh, PA 15213 USA Childrens Hosp Pittsburgh PA USA15213 ens Hosp, Pittsburgh, PA 15213 USA Univ Pittsburgh, Dept Anat & Histol, Pittsburgh, PA 15261 USA Univ Pittsburgh Pittsburgh PA USA 15261 Histol, Pittsburgh, PA 15261 USA Slippery Rock Univ, Dept Phys Therapy, Slippery Rock, PA 16057 USA Slippery Rock Univ Slippery Rock PA USA 16057 Slippery Rock, PA 16057 USA
Titolo Testata:
CLEFT PALATE-CRANIOFACIAL JOURNAL
fascicolo: 4, volume: 37, anno: 2000,
pagine: 370 - 378
SICI:
1055-6656(200007)37:4<370:ACIIPI>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL BLOOD-FLOW; TRANSCRANIAL DOPPLER SONOGRAPHY; SINGLE-SUTURE; CRANIOSYNOSTOTIC RABBITS; SYNDROMIC CRANIOSYNOSTOSIS; GROWTH-PATTERNS; CRANIAL VAULT; VOLUME; HYPERTENSION; CHILDREN;
Keywords:
brain; craniosynostosis; intracranial pressure; neurocapsule; rabbits;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
77
Recensione:
Indirizzi per estratti:
Indirizzo: Mooney, MP Univ Pittsburgh, Dept Oral Med & Pathol, 619 Salk Hall, Pittsburgh, PA 15261 USA Univ Pittsburgh 619 Salk Hall Pittsburgh PA USA 15261 15261 USA
Citazione:
W.K. Fellows-Mayle et al., "Age-related changes in intracranial pressure in rabbits with uncorrected familial coronal suture synostosis", CLEF PAL-CR, 37(4), 2000, pp. 370-378

Abstract

Objective: Chronic, elevated intracranial pressure (ICP) in craniosynostotic infants may result in ocular and neurocapsular problems; however, not all infants exhibit elevated ICP. Clinical ICP studies are further confoundedby small and heterogeneic samples, multiple-suture involvement, and varying surgical management protocols. The present study was designed to describelongitudinal changes in ICP in a large, homogenous sample of rabbits with uncorrected familial, nonsyndromic coronal suture synostosis,Methods: Ninety-one rabbits were divided into four groups: (1) normal rabbits (n = 28), (2) rabbits with delayed-onset coronal suture synostosis (DOCS; n = 25), (3) rabbits with unilateral coronal suture synostosis (UCS; n =12), and (4) rabbits with bilateral coronal suture synostosis (BCS; n = 26), ICP was measured at 24 and 42 days of age using a Codman epidural microtransducer,Results: Rabbits with BCS had a significantly (p < .05) higher mean ICP at25 days of age than rabbits in the other three groups by approximately 146%, However, by 42 days of age, mean ICP in normal control rabbits and rabbits with DOGS was significantly (p < .01) increased compared with their meanICP values seen at 25 days of age, while mean ICP in BCS rabbits significantly (p < .01) decreased (by 32%) over the same time period. ICP in rabbitswith UCS was between that seen in normal control rabbits and rabbits with BCS and did not significantly (p > .05) change over time. Conclusions: These findings suggest that the degree of suture involvement may be related to early increases in ICP. Possible multifactorial explanations for intracranial decompression and compensation in the craniosynostoticrabbit model are discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 19:25:30