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Titolo:
TRANSSPHENOIDAL ADENOMECTOMY IN CUSHINGS-DISEASE VIA A LATERAL RHINOTOMY APPROACH
Autore:
PETRUSON K; JAKOBSSON KE; PETRUSON B; LINDSTEDT G; BENGTSSON BA;
Indirizzi:
GOTHENBURG UNIV,SAHLGRENS HOSP,DEPT OTORHINOLARYNGOL S-41345 GOTHENBURG SWEDEN GOTHENBURG UNIV,SAHLGRENS HOSP,DEPT NEUROSURG S-41345 GOTHENBURG SWEDEN GOTHENBURG UNIV,SAHLGRENS HOSP,DEPT CLIN CHEM & TRANSFUS MED S-41345 GOTHENBURG SWEDEN GOTHENBURG UNIV,SAHLGRENS HOSP,DEPT MED S-41345 GOTHENBURG SWEDEN
Titolo Testata:
Surgical neurology
fascicolo: 1, volume: 48, anno: 1997,
pagine: 37 - 43
SICI:
0090-3019(1997)48:1<37:TAICVA>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
PITUITARY SURGERY; FOLLOW-UP; MICROSURGERY; HYPOPHYSECTOMY; RELAPSE;
Keywords:
CUSHINGS DISEASE; PITUITARY ADENOMA; TRANSSPHENOIDAL SURGERY; TUMOR RECURRENCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
K. Petruson et al., "TRANSSPHENOIDAL ADENOMECTOMY IN CUSHINGS-DISEASE VIA A LATERAL RHINOTOMY APPROACH", Surgical neurology, 48(1), 1997, pp. 37-43

Abstract

BACKGROUND Cushing's disease may be treated by surgical pituitary adenomectomy. We present a surgical approach to the pituitary gland that increases the possibilities of a selective adenomectomy, and compare our results with those of other studies. METHODS A retrospective study of patients with Cushing's disease undergoing transsphenoidal selective adenomectomy via a lateral rhinotomy at Sahlgrenska University Hospital from 1984-93 is presented. Thirty-one patients (26 women, five men; mean age: 44 years, range: 13-15 years) with Cushing's disease were followed for a median time of 4.5 years after operation (range: 1-10 years). Preoperative and postoperative urinary and serum cortisol, and circadian rhythm of serum cortisol were measured. We also measured serum TSH, T4, PRL, FSH, LH, and testosterone as well as urine and plasmaosmolality. RESULTS Our remission rate was 77% and the recurrence rate 3%. Hormonal insufficiency was rare. Hypothyroidism and hypogonadismwere present in 3% of the patients, and diabetes insipidus occurred in 6% of the patients. CONCLUSION Selective adenomectomy with its good opportunities for cure and improvement should be regarded as the treatment of choice for Cushing's disease. Using the lateral rhinotomy approach to the sphenoidal cavity results in good accessibility to the sella turcica and its pituitary adenomas, a low frequency of postoperative pituitary insufficiency, and a high remission rate. (C) 1997 by Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 07:11:53