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Titolo:
Translation initiation factor modifications and the regulation of protein synthesis in apoptotic cells
Autore:
Clemens, MJ; Bushell, M; Jeffrey, IW; Pain, VM; Morley, SJ;
Indirizzi:
St George Hosp, Sch Med, Cellular & Mol Sci Grp, Dept Biochem & Immunol, London SW17 0RE, England St George Hosp London England SW17 0RE Immunol, London SW17 0RE, England Univ Sussex, Sch Biol Sci, Biochem Grp, Brighton BN1 9QG, E Sussex, England Univ Sussex Brighton E Sussex England BN1 9QG BN1 9QG, E Sussex, England
Titolo Testata:
CELL DEATH AND DIFFERENTIATION
fascicolo: 7, volume: 7, anno: 2000,
pagine: 603 - 615
SICI:
1350-9047(200007)7:7<603:TIFMAT>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERNAL-RIBOSOME-ENTRY; TUMOR-NECROSIS-FACTOR; FACTOR 4G EIF4G; ICE/CED-3 FAMILY PROTEASES; CAP-DEPENDENT TRANSLATION; FAS-MEDIATED APOPTOSIS; AMINO-ACID-SEQUENCE; ICE-LIKE PROTEASES; C-MYC PROTEINS; MESSENGER-RNA;
Keywords:
apoptosis; protein synthesis; signal transduction; translational control;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
169
Recensione:
Indirizzi per estratti:
Indirizzo: Clemens, MJ St George Hosp, Sch Med, Cellular & Mol Sci Grp, Dept Biochem & Immunol, Cranmer Terrace, London SW17 0RE, England St George Hosp CranmerTerrace London England SW17 0RE ngland
Citazione:
M.J. Clemens et al., "Translation initiation factor modifications and the regulation of protein synthesis in apoptotic cells", CELL DEAT D, 7(7), 2000, pp. 603-615

Abstract

The rate of protein synthesis is rapidly down-regulated in mammalian cellsfollowing the induction of apoptosis, Inhibition occurs at the level of polypeptide chain initiation and is accompanied by the phosphorylation of thealpha subunit of initiation factor elF2 and the caspase-dependent cleavageof initiation factors elF4G, elF4B, elF2 alpha and the p35 subunit of elF3, Proteolytic cleavage of these proteins yields characteristic products which may exert regulatory effects on the translational machinery. Inhibition of caspase activity protects protein synthesis from long-term inhibition incells treated with some, but not all, inducers of apoptosis, This review describes the initiation factor modifications and the possible signalling pathways by which translation may be regulated during apoptosis, We discuss the significance of the initiation factor cleavages and other changes for protein synthesis, and the implications of these events for our understandingof the cellular changes associated with apoptosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 00:09:47