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Titolo:
The use of SPECT in the diagnosis of Parkinson's disease
Autore:
Emami-Avedon, SS; Ichise, M; Lang, AE;
Indirizzi:
Univ Toronto, Mt Sinai Hosp, Div Nucl Med, Toronto, ON M5G 1X5, Canada Univ Toronto Toronto ON Canada M5G 1X5 l Med, Toronto, ON M5G 1X5, Canada Univ Toronto, Toronto, ON M5G 1X5, Canada Univ Toronto Toronto ON Canada M5G 1X5 ronto, Toronto, ON M5G 1X5, Canada Univ Toronto, Toronto Hosp, Western Div, Movement Disorders Clin, Toronto,ON M5G 1X5, Canada Univ Toronto Toronto ON Canada M5G 1X5 s Clin, Toronto,ON M5G 1X5, Canada
Titolo Testata:
CANADIAN ASSOCIATION OF RADIOLOGISTS JOURNAL-JOURNAL DE L ASSOCIATION CANADIENNE DES RADIOLOGISTES
fascicolo: 3, volume: 51, anno: 2000,
pagine: 189 - 196
SICI:
0846-5371(200006)51:3<189:TUOSIT>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGRESSIVE SUPRANUCLEAR PALSY; PHOTON EMISSION TOMOGRAPHY; MULTIPLE SYSTEM ATROPHY; BETA-CIT SPECT; DOPAMINE TRANSPORTERS; SYMPTOM SEVERITY; I-123; IODINE-123-BETA-CIT; RECEPTORS; BINDING;
Keywords:
basal ganglia; corpus striatum; dopamine; fluorine radioisotopes; iodine radioisotopes; Parkinson disease; radioactive tracers; receptors, dopamine D2; tomography, emission-computed; tomography, emission-computed, single-photon;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Ichise, M Univ Toronto, Mt Sinai Hosp, Div Nucl Med, 600 Univ Ave, Toronto, ON M5G 1X5, Canada Univ Toronto 600 Univ Ave Toronto ON Canada M5G 1X5 1X5, Canada
Citazione:
S.S. Emami-Avedon et al., "The use of SPECT in the diagnosis of Parkinson's disease", CAN ASSOC R, 51(3), 2000, pp. 189-196

Abstract

This article looks briefly at the latest efforts to develop an objective diagnostic marker for Parkinson's disease on single-photon emission computedtomography (SPECT). Traditionally, the diagnosis of idiopathic Parkinson'sdisease has been based on clinical criteria, However, these predict the pathologic diagnosis in only 80% of patients suspected of having the disease. Since a correct diagnosis is essential for prognosis, effective treatment and research, the search has continued for objective markers. The latest developments in nuclear medicine have come the closest in making such a marker clinically available. These developments are based on SPECT and positron-emission tomographic imaging of the basal ganglia using specific radio-labelled dopaminergic-receptor tracers. SPECT radiotracers target either the pre- or postsynaptic component of the dopaminergic system in the basal ganglia. These techniques show great promise in the early diagnosis of PD as wellas in measuring its progression.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 15:16:19