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Titolo:
Deoxycorticosterone acetate-salt hypertensive rats display gender-related differences in ETB receptor-mediated vascular responses
Autore:
Passaglia, RCAT; David, FL; Fortes, ZB; Nigro, D; Scivoletto, R; de Carvalho, MHC;
Indirizzi:
Univ Sao Paulo, Inst Biomed Sci, Dept Pharmacol, BR-05508900 Sao Paulo, SP, Brazil Univ Sao Paulo Sao Paulo SP Brazil BR-05508900 BC00 Sao Paulo, SP, Brazil
Titolo Testata:
BRITISH JOURNAL OF PHARMACOLOGY
fascicolo: 5, volume: 130, anno: 2000,
pagine: 1092 - 1098
SICI:
0007-1188(200007)130:5<1092:DAHRDG>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY VASOCONSTRICTION; GONADAL-HORMONES; BLOOD-VESSELS; ENDOTHELIN; ACTIVATION; ANTAGONIST; EXPRESSION;
Keywords:
DOCA-salt hypertension; endothelin; gender; ETB receptors; IRL-1620;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Passaglia, RCAT Univ Sao Paulo, Inst Biomed Sci, Dept Pharmacol, Av Lineu Prestes 1524, BR-05508900 Sao Paulo, SP, Brazil Univ Sao Paulo Av Lineu Prestes 1524 Sao Paulo SP Brazil BR-05508900 BC
Citazione:
R.C.A.T. Passaglia et al., "Deoxycorticosterone acetate-salt hypertensive rats display gender-related differences in ETB receptor-mediated vascular responses", BR J PHARM, 130(5), 2000, pp. 1092-1098

Abstract

1 Male DOCA-salt rats exhibit vasoconstriction upon ETB activation. Because hypertension is less severe in female than male DOCA rats, we hypothesized that female DOCA rats would display attenuated ETB vasoconstrictor responses.2 Uninephrectomized Wistar rats received DOCA and drinking water containing NaCl/KCl, Control rats received vehicle and tap water. Systolic blood pressure was higher in male vs female DOCA rats. Responses to endothelin-1 (ET-1), IRL-1620, an ETB agonist, and acetylcholine were evaluated in isolatedaortas and in vivo in the mesenteric microcirculation.3 Endothelium-denuded aortas from male, but not female. DOCA rats displayed increased sensitivity to ET-1. IRL-1620 contracted aortas from male DOCA rats, but not control or female DOCA aortas. Noradrenaline-constricted and endothelium-intact aortas from male, but not female, DOCA rats displayed increased relaxation to IRL-1620 compared to control aortas.4 In vivo, increased vasoconstriction to ET-1 was observed in male and female DOCA rats. IRL-1620 induced vasodilation in control rats, but vasoconstriction in male DOCA rats. There were minimal changes in diameter in vessels from female DOCA rats.5 The initial fall in blood pressure induced by ET-1 and IRL-1620 was attenuated in male DOCA rats. Bosentan, a mixed ETA/ETB, receptor antagonist, lowered blood pressure in male and female DOCA rats, but a greater and marked decrease occurred in the male DOCA group.6 The gender-related differences in ET-1/ETB-mediated effects both in the vasculature and blood pressure suggest that sex-related functional up-regulation of ETB receptors may play a role in the more severe hypertension in male DOCA hypertensive rats.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 11:47:34