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Titolo:
A paraneoplastic mixed bullous skin disease: breakdown in tolerance to multiple epidermal antigens
Autore:
Musette, P; Joly, P; Gilbert, D; Marinho, E; Crickx, B; Tron, F; Belaich, S; Descamps, V;
Indirizzi:
Hop Bichat, Dept Dermatol, F-75018 Paris, France Hop Bichat Paris FranceF-75018 at, Dept Dermatol, F-75018 Paris, France Hop Bichat, Dept Pathol, F-75018 Paris, France Hop Bichat Paris France F-75018 chat, Dept Pathol, F-75018 Paris, France Hop Charles Nicolle, Unite INSERM US19, F-76031 Rouen, France Hop Charles Nicolle Rouen France F-76031 ERM US19, F-76031 Rouen, France Hop Charles Nicolle, IRF 23, F-76031 Rouen, France Hop Charles Nicolle Rouen France F-76031 , IRF 23, F-76031 Rouen, France
Titolo Testata:
BRITISH JOURNAL OF DERMATOLOGY
fascicolo: 1, volume: 143, anno: 2000,
pagine: 149 - 153
SICI:
0007-0963(200007)143:1<149:APMBSD>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN AUTOANTIBODIES; PEMPHIGUS-VULGARIS; PASSIVE TRANSFER; INDIRECT IMMUNOFLUORESCENCE; DESMOSOMAL PLAQUE; NEONATAL MICE; IN-VIVO; ANTIBODIES; IMMUNOBLOT; FOLIACEUS;
Keywords:
bullous skin disease; lymphoma; paraneoplastic skin disease; tolerance;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Descamps, V Hop Bichat, Dept Dermatol, 46 Rue H Huchard, F-75018 Paris, France Hop Bichat 46 Rue H Huchard Paris France F-75018 aris, France
Citazione:
P. Musette et al., "A paraneoplastic mixed bullous skin disease: breakdown in tolerance to multiple epidermal antigens", BR J DERM, 143(1), 2000, pp. 149-153

Abstract

We report a new type of paraneoplastic mixed bullous skin disease in a patient with a B-cell lymphoma associated with monoclonal IgM kappa paraproteinaemia. The patient's clinical and histological features were reminiscent of bullous pemphigoid. Characterization of antiepidermal antibodies by immunoblotting and indirect immunoelectron microscopy demonstrated a novel pattern of reactivity: IgG antibodies were directed against desmoplakins I-II and BPAG2, and were associated with antidesmoglein 3 polyclonal IgM antibodies. Such an autoreactive pattern involving antidesmoplakins, anti-BPAG2 and antidesmoglein 3 antibodies has not been previously reported. It reflects the breakdown of tolerance to multiple epidermal antigens observed in some patients with malignancy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/07/20 alle ore 04:30:34