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Titolo:
Uneven distribution of HPV 16 E6 prototype and variant (L83V) oncoprotein in cervical neoplastic lesions
Autore:
Andersson, S; Alemi, M; Rylander, E; Strand, A; Larsson, B; Sallstrom, J; Wilander, E;
Indirizzi:
Karolinska Inst, Danderyd Hosp, Dept Obstet & Gynaecol, Stockholm, Sweden Karolinska Inst Stockholm Sweden t Obstet & Gynaecol, Stockholm, Sweden Univ Uppsala Hosp, Dept Genet & Pathol, Sect Clin Cytol, Uppsala, Sweden Univ Uppsala Hosp Uppsala Sweden thol, Sect Clin Cytol, Uppsala, Sweden Univ Uppsala Hosp, Dept Med Sci Dermatol & Venereol, Uppsala, Sweden Univ Uppsala Hosp Uppsala Sweden i Dermatol & Venereol, Uppsala, Sweden
Titolo Testata:
BRITISH JOURNAL OF CANCER
fascicolo: 3, volume: 83, anno: 2000,
pagine: 307 - 310
SICI:
0007-0920(200008)83:3<307:UDOH1E>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYMERASE CHAIN-REACTION; HUMAN-PAPILLOMAVIRUS DNA; INTRAEPITHELIAL NEOPLASIA; NATURAL-HISTORY; CANCER; IDENTIFICATION; PROGRESSION; PREVALENCE; WORLDWIDE; WOMEN;
Keywords:
HPV16; E6 gene; polymorphism; cervical adenocarcinomas;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Wilander, E Karolinska Inst, Danderyd Hosp, Dept Obstet & Gynaecol, Stockholm, Sweden Karolinska Inst Stockholm Sweden ynaecol, Stockholm, Sweden
Citazione:
S. Andersson et al., "Uneven distribution of HPV 16 E6 prototype and variant (L83V) oncoprotein in cervical neoplastic lesions", BR J CANC, 83(3), 2000, pp. 307-310

Abstract

A previous Swedish study revealed that both prototype and variant HPV16 E6oncoprotein, occur in about equal numbers in high-grade cervical intraepithelial neoplasia (HCIN), whereas Variant HPV16 predominates in invasive cervical squamous carcinoma. Most of the malignant HPV16 Variants contain a common mutation, L83V, in the E6 oncoprotein. in the present investigation, 28 HPV16 positive, invasive cervical adenocarcinomas were collected from a total number of 131 adenocarcinomas. These HPV-16-positive cases were evaluated with analysis of the E6 gene, using a recently described PCR-SSCP method for identification of the specific mutation (L83V) in the E6 gene. The results obtained were correlated to findings in 103 preinvasive, HCIN, and 31invasive cervical squamous carcinomas also infected with HPV16. The HPV-16E6 variant L83V was present in 40% of the HCIN lesions, in 54% of the invasive adenocarcinomas, in comparison to 81% of the invasive squamous carcinomas. The difference between HCIN and squamous carcinomas was statistically significant, P < 0.001, whereas the difference between HCIN and invasive adenocarcinomas was not statistically significant, P = 0.604. Prototype HPV16and its E6 variant L83V are both prevalent in preinvasive and invasive cervical lesions in Swedish women. However, the obvious predominance of HPV16 variant in squamous carcinomas was not seen in adenocarcinomas. A single amino-acid shift in the HPV16 E6 gene appears to result in a different transforming potential in squamous and glandular cervical lesions. (C) 2000 Cancer Research Campaign.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 06:39:48