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Titolo:
Evaluation of CMV/human herpes virus-6 positivity in bronchoalveolar lavage fluids as early detection of acute GVHD following BMT: evidence of a significant relationship
Autore:
Takemoto, Y; Takatsuka, H; Wada, H; Mori, A; Saheki, K; Okada, M; Tamura, S; Fujimori, Y; Okamoto, T; Kakishita, E; Kanamura, A;
Indirizzi:
Hyogo Coll Med, Dept Internal Med 2, Nishinomiya, Hyogo 6638501, Japan Hyogo Coll Med Nishinomiya Hyogo Japan 6638501 miya, Hyogo 6638501, Japan Kinki Univ, Dept Internal Med 3, Osaka, Japan Kinki Univ Osaka JapanKinki Univ, Dept Internal Med 3, Osaka, Japan
Titolo Testata:
BONE MARROW TRANSPLANTATION
fascicolo: 1, volume: 26, anno: 2000,
pagine: 77 - 81
SICI:
0268-3369(200007)26:1<77:EOCHVP>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE-MARROW TRANSPLANTATION; STEM-CELL TRANSPLANTATION; VERSUS-HOST DISEASE; CYTOMEGALOVIRUS DISEASE; PREEMPTIVE GANCICLOVIR; RISK-FACTORS; RECIPIENTS; INFECTION; HERPESVIRUSES;
Keywords:
CMV; HHV-6; GVHD; BMT; bronchoalveolar lavage fluids;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Takemoto, Y Hyogo Coll Med, Dept Internal Med 2, 1-1 Mukogawacho, Nishinomiya, Hyogo 6638501, Japan Hyogo Coll Med 1-1 Mukogawacho Nishinomiya Hyogo Japan 6638501
Citazione:
Y. Takemoto et al., "Evaluation of CMV/human herpes virus-6 positivity in bronchoalveolar lavage fluids as early detection of acute GVHD following BMT: evidence of a significant relationship", BONE MAR TR, 26(1), 2000, pp. 77-81

Abstract

We evaluated the relationship between CMV and human herpes virus-6 (HHV-6)reactivation and the incidence of grades 2 to 4 acute GVHD post BMT. Bronchoalveolar lavage fluid (BALF) samples extracted from 54 BMT recipients on post-BMT day 35 were analyzed by PCR for detection of CMV DNA, HHV-6 DNA and CMV plus HHV-6 DNA, CMV DNA was detected in 26 patients and 13 (50%) developed grades 2 to 4 acute GVHD. Of the 28 who were CMV negative, only six (21.4%) developed grades 2 to 4 acute GVHD, HHV-6 was detected in 18 patients, and 11 (61.1%) developed grades 2 to 4 acute GVHD, Of the 36 who were HHV-6 negative, only eight (22.2%) developed grades 2 to 4 acute GVHD. CMV and HHV-6 were detected in 13 patients, and eight (61.5%) developed grades 2 to 4 acute GVHD, Of the 23 who were negative for both CMV and HHV-6, only three (13%) developed grades 2 to 4 acute GVHD, In all experiments, the difference between the groups was significant (P < 0.05, P < 0.05 and P < 0.01;respectively). We conclude that herpesvirus infection, in particular CMV concurrent with HHV-6 reactivation, is predictive of moderate to severe acute GVHD.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 10:26:42