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Titolo:
Enhanced binding of aminoglycoside dimers to a "dimerized" A-site 16S rRNAconstruct
Autore:
Tok, JBH; Huffman, GR;
Indirizzi:
Indiana Univ Purdue Univ, Dept Chem, Ft Wayne, IN 46805 USA Indiana Univ Purdue Univ Ft Wayne IN USA 46805 em, Ft Wayne, IN 46805 USA
Titolo Testata:
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
fascicolo: 14, volume: 10, anno: 2000,
pagine: 1593 - 1595
SICI:
0960-894X(20000717)10:14<1593:EBOADT>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
RNA-BINDING; HAMMERHEAD RIBOZYME; RIBOSOMAL-RNA; ANTIBIOTICS; INHIBITION; RECOGNITION; DESIGN; REV;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Tok, JBH Indiana Univ Purdue Univ, Dept Chem, 2101 E Coliseum Blvd, Ft Wayne, IN 46805 USA Indiana Univ Purdue Univ 2101 E Coliseum Blvd Ft Wayne IN USA 46805
Citazione:
J.B.H. Tok e G.R. Huffman, "Enhanced binding of aminoglycoside dimers to a "dimerized" A-site 16S rRNAconstruct", BIOORG MED, 10(14), 2000, pp. 1593-1595

Abstract

In this work, we investigated the binding of a series of dimeric aminoglycoside molecules to (i) a 27 nt A-site 16S rRNA construct, and (ii) an artificially grafted 46 nt 'dimerized' A-site 16S rRNA construct. It was observed that the dissociation constants of dimeric aminoglycosides to the dimerized A-site 16S rRNA construct can achieve up to approximately 19-fold enhancement compared to the monomeric aminoglycoside molecules. (C) 2000 ElsevierScience Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 07:59:33