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Titolo:
Molecular basis for differing antineurogenic effects of GATA-1a and GATA-1b in Xenopus
Autore:
Chen, HD; Huang, YK; Ault, K; Wong, GW; Lin, MCM; Chen, HC; Kung, HF;
Indirizzi:
NICHD, Endocrinol & Reprod Res Branch, NIH, Bethesda, MD 20892 USA NICHD Bethesda MD USA 20892 eprod Res Branch, NIH, Bethesda, MD 20892 USA NCI, Lab Biochem Physiol, Div Basic Sci, FCRDC,NIH, Frederick, MD 21702 USA NCI Frederick MD USA 21702 Basic Sci, FCRDC,NIH, Frederick, MD 21702 USA Univ Hong Kong, Inst Mol Biol, Hong Kong, Hong Kong, Peoples R China Univ Hong Kong Hong Kong Hong Kong Peoples R China Kong, Peoples R China
Titolo Testata:
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
fascicolo: 2, volume: 273, anno: 2000,
pagine: 614 - 620
SICI:
0006-291X(20000705)273:2<614:MBFDAE>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSCRIPTION FACTOR GATA-1; DNA-BINDING FACTOR; DIFFERENTIAL REGULATION; EXPRESSION; GENES; NEURALIZATION;
Keywords:
transcription factor; chimeras; untranslated regions; erythropoiesis; neurogenesis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Chen, HD NICHD, Endocrinol & Reprod Res Branch, NIH, Bethesda, MD 20892 USA NICHD Bethesda MD USA 20892 Branch, NIH, Bethesda, MD 20892 USA
Citazione:
H.D. Chen et al., "Molecular basis for differing antineurogenic effects of GATA-1a and GATA-1b in Xenopus", BIOC BIOP R, 273(2), 2000, pp. 614-620

Abstract

The erythroid transcription factor GATA-1 in Xenopus has been cloned as a pair of presumably duplicated genes designated as xGATA-1a and xGATA-1b. Although both xGATA-1a and xGATA-1b are able to stimulate erythropoiesis, only xGATA-1b is capable of inhibiting neurogenesis in Xenopus embryos. Chimeras of these two genes were constructed by permuting coding and untranslatedregions (UTR) on both ends of these two xGATA-1, and their neurogenesis-inhibitory effects were studied. These results reveal that (1) sequence variations between the coding regions alone do not account for the neurogenesis effect; (2) 3' UTR of xGATA-1a causes the loss of the neurogenesis inhibition of xGATA-1b; (3) 3' UTR of xGATA-1b is essential to inhibit neurogenesis. In addition, the presence of either UTR does not affect the stability of the mRNA in vitro. These observations suggest the influence of 3' UTR in xGATA-1 on the inhibition of neurogenesis. (C) 2000 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 01:40:47