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Titolo:
Oxidation of LDL by myeloperoxidase and reactive nitrogen species - Reaction pathways and antioxidant protection
Autore:
Carr, AC; McCall, MR; Frei, B;
Indirizzi:
Oregon State Univ, Linus Pauling Inst, Corvallis, OR 97331 USA Oregon State Univ Corvallis OR USA 97331 ng Inst, Corvallis, OR 97331 USA
Titolo Testata:
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
fascicolo: 7, volume: 20, anno: 2000,
pagine: 1716 - 1723
SICI:
1079-5642(200007)20:7<1716:OOLBMA>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY-LIPOPROTEIN; HUMAN ATHEROSCLEROTIC LESIONS; HYDROGEN-PEROXIDE-CHLORIDE; MACROPHAGE-MEDIATED OXIDATION; HYPOCHLORITE-MODIFIED LDL; NITRIC-OXIDE SYNTHASE; CELL-FREE SYSTEMS; LIPID-PEROXIDATION; ALPHA-TOCOPHEROL; APOLIPOPROTEIN B-100;
Keywords:
low density lipoproteins; myeloperoxidase; reactive nitrogen species; vitamin C; vitamin E;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
104
Recensione:
Indirizzi per estratti:
Indirizzo: Frei, B Oregon State Univ, Linus Pauling Inst, 571 Weniger Hall, Corvallis, OR 97331 USA Oregon State Univ 571 Weniger Hall Corvallis OR USA 97331 7331 USA
Citazione:
A.C. Carr et al., "Oxidation of LDL by myeloperoxidase and reactive nitrogen species - Reaction pathways and antioxidant protection", ART THROM V, 20(7), 2000, pp. 1716-1723

Abstract

Oxidative modification of low density lipoprotein (LDL) appears to play animportant role in atherogenesis. Although the precise mechanisms of LDL oxidation in vivo are unknown, several lines of evidence implicate myeloperoxidase and reactive nitrogen species, in addition to ceruloplasmin and 15-lipoxygenase. Myeloperoxidase generates a number of reactive species, including hypochlorous acid, chloramines, tyrosyl radicals, and nitrogen dioxide. These reactive species oxidize the protein, lipid, and antioxidant components of LDL. Modification of apolipoprotein B results in enhanced uptake of LDL by macrophages with subsequent formation of lipid-laden foam cells. Nitric oxide synthases produce nitric oxide and, under certain conditions, superoxide radicals. Numerous other sources of superoxide radicals have been identified in the arterial wall, including NAD(P)H oxidases and xanthine oxidase, Nitric oxide and superoxide readily combine to form peroxynitrite, a reactive nitrogen species capable of modifying LDL. In this review, we examine the reaction pathways involved in LDL oxidation by myeloperoxidase and reactive nitrogen species and the potential protective effects of the antioxidant vitamins C and E.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 10:28:26